Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, ...

We report on an abdominal pregnancy in human immunodeficiency virus-positive mother, currently on antiretroviral therapy, which was discovered incidentally while training the obstetric ultrasound capacity building program. Although abdominal pregnancy is a rare form of ectopic pregnancy, it may be more common in women with HIV infection because they tend to have a higher rate of sexually transm...

Several autoimmune diseases have been reported to be associated with common variable immunodeficiency disease (CVID), including rheumatoid arthritis and Sjögren's syndrome. On the other hand, approximately 20-30% of patients with rheumatoid arthritis develop secondary Sjögren's syndrome. A 26-year-old woman had a 6-year history of chronic symmetric polyarthritis and 3-year history of sicca synd...

Primary immunodeficiency diseases (PIDs) is a diverse group of diseases, characterized by a defect in the immune system. These patients are susceptible to recurrent respiratory infections, gastrointestinal problems, autoimmune diseases, and malignancies. In most cases, patients with primary immunodeficiency disorders have genetic defects and are monogenic disorders that follow a simple Mendelia...

introduction: oral manifestations can be the first signs of human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids) and a useful marker for the progression of this disease. the present study aimed to determine the prevalence of oral manifestations and examine their relationship with socio-demographic factors in hiv-positive patients in the health centers affiliated to zahedan...

primary immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. allogeneic hematopoietic stem cell transplantation (hsct) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. in this presentation basic and practical aspects of hsct are presented, with a...

The immune system is composed of a variety of cells and proteins viz. lymphocytes, phagocytes, and cytokines, for which one of the principal functions is microbial defense. Abnormalities of the immune system (IS), particularly the secondary immunodeficiency, are due to old age, several pathologic conditions (diabetes mellitus, lymphohematologic neoplasias, malnutrition, HIV/AIDS etc.), surgical...

Adaptive immune mechanisms recognize and neutralize foreign molecules or microorganisms in a specific manner. Lymphocytes, B and T cells, can respond specifically to thousands of nonself materials. Adaptation is further acquired with memory of previous infections. Immunodeficiencies impair the functioning of the immune system. Deficiencies are highly variable with regard to symptoms, phenotype,...

Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the eff...