The objective is to examine how the flux of neurotransmitter glutamate from neurons to the extracellular fluid, as measured by the rate of 13C enrichment of extracellular glutamate (GLUECF), changes in response to seizures in the kainate-induced rat model of temporal-lobe epilepsy. Following unilateral intrahippocampal injection of kainate, GLUECF was collected by microdialysis from the CA1/CA3...

Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas aff...

Biomedical scientific communities increasingly articulate concern about the unsustainable status quo of traditional publishing paradigms [2], feeding an ongoing debate and consideration of alternative publishing models [3]. Seizing an opportune moment to contribute to the ongoing assessment and refinement of scholarly publishing in biomedical education, research, and patient care, an energetic ...

Consultant dermatologist Tanya Bleiker talks to Helen Jones about how she has developed her career by seizing every opportunity that come way

Dynamic capabilities have typically been conceptualized as sensing, seizing, and transforming. This article explores the interplay of these procedural dimensions employing a longitudinal case study Axel Springer, leading media corporation that has exercised dynamic to convert from print publisher an internet company. Insightful evidence is produced interviews with current former top managers. T...

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BRAIN SEIZURES, AS IN EPILEPSY, are characterized by massively synchronous firing of neurons. Given the extraordinary complexity of the human brain, it is surprising that epilepsy is not a more common complaint. Episodic brain seizures currently affect 1% of the human population, and causes for the syndrome range from hereditary effects to brain injuries and infectious diseases (Berg 2011). To ...

Economic and social change have brought great opportunities and threats to adolescent health for rich and poor nations alike. The health transition, together with changes in adolescent social roles, has shifted the burden from childhood infectious diseases towards adolescent injuries and health-jeopardising behaviours in all but the poorest countries. Fortunately, research has clarifi ed many d...