نتایج جستجو برای: selective structure function
تعداد نتایج: 2700917 فیلتر نتایج به سال:
In this study, a new series of 5-substituted 1-benzyl-2-(methylsulfonyl)-1-H-imidazolewith atypical structure-activity relationship was designed, synthesized, and biologicalevaluated as selective cyclooxygenase-2 inhibitors. Docking studies revealed that althoughthe pharmacophoric substitute of the compound 5b, methylsulfonyl group, has been directlyattached to the central ring, it is in the sa...
The International Olympic Committee Medical Commission (IOC-MC) requires notification for use of a beta(2) agonist at the Winter Olympic Games in Salt Lake City. This notification will be required seven days before the event and must be accompanied by objective evidence that justifies the need to use one. The IOC-MC has expressed the viewpoint that, at present, eucapnic voluntary hyperpnoea (EV...
although the genome is defined by its primary sequence, its functional properties, are determined by far more complex mechanisms and depend on multiple layers of nuclear organization. the architecture of the nucleus includes two overlapping structures: the chromatin and a framework structure named the nuclear matrix. ultra-structural studies reveal that the nuclear matrix is a network consistin...
Acetylation and deacetylation of histones are important in regulating gene expression and play a key role in modification of gene transcription. Specific HDACs isoforms can be regarded as a target for cancer therapy avoiding side-effects, HDAC6 with a unique physiological function and structure has become a hot issue recently. The unique isoform HDAC6 is involved in tumorigenesis, development a...
Background: Cone snails are a rich source of αconotoxins that target nAChRs. Result: A new α-conotoxin TxIB potently blocked α6/α3β2β3 nAChRs with high selectivity. Conclusion: TxIB is an effective inhibitor of α6/α3β2β3 nAChRs. Its structure was determined by NMR. Significance: TxIB is a new, uniquely selective ligand for querying the structure and function of nAChRs and designing therapeutic ...
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