The problem discussed is the relationship between the firing of single neurons in sensory pathways and subjectively experienced sensations. The conclusions are formulated as the following five dogmas: 1. To understand nervous function one needs to look at interactions at a cellular level, rather than either a more macroscopic or microscopic level, because behaviour depends upon the organized pa...

The effect of menthol on the discharge pattern of feline nasal and lingual cold receptors was analyzed in order to elucidate the underlying sensory transducer mechanism. A repetitive beating activity and burst (grouped) discharges were observed in both cold receptor populations at constant temperatures and after rapid cooling. An analysis of the impulse activity revealed a cyclic pattern of imp...

In all vertebrates, self-generated body motion necessitates compensatory eye movements to avoid perturbation of visual processing. This evolutionary conserved motor action is traditionally ascribed to the transformation of visuovestibular sensory signals into extraocular motor commands. During rhythmic locomotor activity in Xenopus laevis, however, intrinsic efference copies arising from the sp...

Responses to gentle touch in young Xenopus tadpoles are mediated by spinal cord sensory Rohon-Beard neurons. Tadpoles also respond to noxious stimuli that elicit 'skin impulses', which propagate between epithelial cells over the whole body surface, somehow entering the CNS to generate a response. After hatching (~48 h post-fertilization), skin impulse signals enter the CNS only via cranial nerv...

Transmission from single, identified hair follicle afferent (HFA) nerve fibers to their target neurons of the cuneate nucleus was examined in anesthetized cats by means of paired recording from individual cuneate neurons and from fine, intact fascicles of the lateral branch of the superficial radial nerve in which it is possible to identify and monitor the activity of each group II fiber. Selec...

Post-traumatic stress disorder is characterized by exaggerated threat response, and theoretical accounts to date have focused on impaired threat processing and dysregulated prefrontal-cortex-amygdala circuitry. Nevertheless, evidence is accruing for broad, threat-neutral sensory hyperactivity in post-traumatic stress disorder. As low-level, sensory processing impacts higher-order operations, su...

the impulse oscillation system (ios) measures respiratory impedance (zrs) in terms of resistance (rrs) and reactance (xrs) at multiples of 5 hz. these measurements can be used clinically to help diagnose and monitor respiratory disorders, independent of effort. there is, as yet, no information on reference values for ios in iranian adolescents. the predictive equation for resistance and impedan...

Zinc is a substance that regulates neural excitability by binding whit sodium channel and potassium channel. The efficiency of free zinc ion, make down the neural survival rate, reduced the peak amplitude of Na+ and make depolarization Na channel, increased the peak amplitude of transition outward k+ currents and delayed rectifier. Also it is an effective blocker of one subtype of tetrodoxine (...