A correlation between high plasma serotonin levels and total pulmonary resistance was reported in more than 80% of pulmonary hypertensive patients. When submitted to chronic hypoxia (10% O(2) for more than 3 weeks), wild-type mice develop lung vascular remodeling and pulmonary hypertension. We previously reported that, in contrast, the development of these hypoxia-dependent alterations is total...

Purpose of the study. Was to analyze levels biogenic amines (serotonin and its metabolite 5-HIAA, dopamine, norepinephrine histamine) in lung tissues patients with cancer previous COVID-19 infection. Patients methods. The study was carried out on samples intact tissues, tumor peritumoral obtained during open biopsy while performing radical surgery from morphologically verified non-small cell (N...

Disruption of the serotonin system has been implicated in anxiety and depression and a related genetic variation has been identified that may predispose individuals for these illnesses. The relationship of a functional variation of the serotonin transporter promoter gene (5-HTTLPR) on serotonin transporter binding using in vivo imaging techniques have yielded inconsistent findings when comparin...

Background & Aims: Labor conditions cause stress and anxiety specifically in nulliparous women and hence the chance of a normal vaginal delivery is reduced. According to some studies lavender scent improves mood and reduces stress and anxiety. The purpose of this study was to investigate the effect of lavender scent on anxiety status in nulliparous women and also to determine changes in plasma ...

Introduction: The aim of this research was to compare active and passive recovery after a session of intense exhaustive training on the level of serotonin in the serum of the runners. Materials and Methods: In this semi-experimental study, 26 male elite runners were randomly assigned to two groups of active (n=12) and passive (n=14) recovery. Half an hour before the start of the training, 5 ...

The subfornical organ (SFO) receives significant serotonergic innervation. However, few reports have examined the functional effects of serotonin on SFO neurons. This study characterized the effects of serotonin on spontaneously firing SFO neurons in the rat brain slice. Of 31 neurons tested, 80% responded to serotonin (1-100 μM) with either an increase ( n = 15) or decrease ( n = 10) in sponta...

NeuroGénétique and Stress, INSERM U471, Institut F. Variants at serotonin transporter and 2A receptor genes predict cooperative behavior differentially according to presence of punishment Proc. Abstract Full Text PDF.Corticosteroidserotonin interactions in the neurobiological mechanisms of stress-related disorders. Laurence Lanfumey a,b, Raymond Mongeau a,b, Charles.of acute and chronic stress ...

1 Laboratory of Neuropharmacology and Neural Tumor Biology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil 2 Cancer Research Laboratory, University Hospital Research Center, Federal University of Rio Grande do Sul, Porto Alegre, Brazil 3 National Institute for Translational Medicine, Porto Alegre, Brazil *Correspond...

The effect of endogenous serotonin on long-term potentiation (LTP) in region CAI was studied by blocking 5-HT2 receptors with ketanserin in rat hippocampal slices. Such a block significantly en-hanced long-term potentiation of the CAI population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. This implies that serotonin acts on 5-HT2 receptors in CAI...

II DECLARATION Herewith I declare that the experiments of the present thesis were carried out under the supervision of Univ. Prof. Dr. Michael Freissmuth. Each article in the " Results " section contains a small introduction with the information which experiments were conducted by me. purified the peptides used for the ATPase assays in section 2.1 fig.1 C, D.