The correlation between antibiotic concentrations in serum, serum bactericidal activity, and results of therapy was studied in rabbits with streptococcal endocarditis. Five days of procaine penicillin G reduced bacterial titers to <10 per g in 12 of 14 vegetations in rabbits receiving 75,000 U intramuscularly every 6 h and 10 of 20 in rabbits given 37,500 U. Ten days of 18,750 U every 6 h did n...

regarding the high prevalence of hyperlipidaemia, which is one of the major risk factors of cardiovascular disease, and uncertain reports about the relation between periodontal disease and serum lipid profile, this study was conducted to assess this relation. the historical cohort study was conducted on 52 cases including 26 persons with chronic periodontitis as case group, and 26 healthy subje...

the relation between serum osmolality, glucose, sodium, bicarbonate, arterial ph, bun and level of consciousness was studied in 189 patients with diabetic ketoacidosis (dka). there was much overlap between all laboratory values among various groups, even when there was a statistically significant difference. to find a better predictor, we defined a new factor as serum osmolality/arterial ph. th...

background: it seems that serum vitamin d levels are one of the potential environmental factors affecting the severity of multiple sclerosis (ms). in this study, we aim to evaluate vitamin d levels in ms patients and healthy subjects and assess the relationship between vitamin d level and disability. methods: in this case-control study, 168 rapid relapsing ms patients and 168 matched healthy co...

the previous large retrospective studies demonstrated that treatment with statins reduces both the incidence of prostate cancer by 50% and serum prostate specific antigen (psa) level up to 40%. however the main problem in those studies was the absence of control groups of men with hypercholesterolemia without statin treatment. we performed a small prospective controlled clinical trial to assess...

Cephalothin is 7-(thiophene-2-acetamido) cephalosporanic acid; it was prepared by N-acylation of the nucleus of cephalosporin C, 7-aminocephalosporanic acid. Cephalothin had a broad spectrum of antibiotic activity that was essentially unaffected by human serum or inoculum level, the activity of penicillinase, or pH variation of the growth medium. In vitro development of resistance by staphyloco...

Eight recent isolates of Neisseria gonorrhoeae with high-level non-beta-lactamase-mediated penicillin resistance were investigated. The penicillin-binding proteins of these strains were found to have reduced affinity for radiolabeled penicillin. Testing for known resistance genes showed that these were present in the resistant isolates. Genetic transformation was used to construct strains with ...

Australian and New Zealand Journal of Public Health 1 © 2015 Public Health Association of Australia Benzathine benzylpenicillin G (BPG) is a beta-lactamase antibiotic developed in 1951.1 Administered intramuscularly, BPG has low in vivo solubility, producing prolonged serum penicillin concentrations. This makes BPG suitable for treating penicillin-sensitive organisms responsive to extended, low...

Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 micrograms/ml, with a mean drug level in cerebrospinal fluid of 1.3 micrograms/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline...

Case report R. B., an 1 8-year-old schoolgirl with rheumatic mitral stenosis, developed subacute bacterial endocarditis in May 1944. After a preliminary and unsuccessful course of penicillin treatment elsewhere, she was transferred to the New Haven Hospital in September 1944. The infecting bacterium, Streptococcus vridans, proved relatively sensitive to penicillin, and the administration of 12,...