Osteolytic bone diseases are commonly presented with enhanced osteoclast formation and bone resorption. Sesquiterpene lactone natural compounds have been found to possess anti-inflammatory and immune-modulation effects. Here, we identified three germacrane sesquiterpenes using computer-based virtual screening for the structural similarity with sesquiterpene lactone, parthenolide. We showed that...

Worms are becoming difficult pests to control since many insecticides are now forbidden and the present alternatives are insufficiently effective. Antifeedants of plant origin may have potential against such pests. In this work, several diterpenoids, flavones and coumarins extracted from plants were assayed as antifeedant agents against Spodoptera littoralis larvae. Among these compounds, four ...

Coumarins, as a family of molecules, exhibit a wide range of fluorescence emission properties. In many cases, this fluorescence is extremely sensitive to the local environment of the molecule, especially the local polarity and microviscosity. In addition, coumarins show a wide range of size, shape, and hydrophobicity. These properties make them especially useful as fluorescent probes of heterog...

A novel and metal-free procedure has been developed for the construction of 3-sulfonated coumarins via the direct difunctionalization of alkynoates with sulfonylhydrazides. The present protocol, which simply utilizes TBAI as the catalyst and TBHP as the oxidant, provides a convenient and highly efficient approach to construct a series of sulfonated coumarins with high regioselectivity and good ...

objective during the last three decades sesquiterpenoid lactones have emerged as one of the largest groups of plant products with over 3000 naturally occurring substances known. the genus artemisia characteristically contains this biologically active type of secondary metabolites. with respect to increasing interest in the cytotoxic, antibiotic, phototoxic and antineoplastic activities of sesqu...

BACKGROUND Coronary angioplasty frequently creates a thrombogenic surface, with subsequent mural thrombosis that may lead to acute complications and possibly stimulates the development of restenosis. Whether coumarins can prevent these complications is unclear. The objective of this open, randomized trial was to assess the clinical effect of coumarins started before coronary angioplasty and con...

Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19,...

The antibacterial activity of a series of simple coumarins was evaluated against 8 microorganisms, including three Gram-positive (Staphylococcus aureus, beta-hemolytic Streptococcus and Streptococcus pneumoniae) and five Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis and Haemophilus influenzae), using the microdilution broth method. Th...

Z. Naturforsch. 55c, 5 2 8 -5 3 3 (2000); received April 5/April 20. 2000 Pelargonium Species, Umckaloabo, Coumarins, Oxygenation Pattern The coumarin patterns of Pelargonium sidoides DC. and Pelargonium reniforme CURT., forming the origin of the herbal medicine “umckaloabo”, were analysed and compared for therapeutic equivalence. For both species, members of triand tetraoxygenated coumarins al...

Sesquiterpene lactones constitute a large and diverse group of biologically active plant chemical that have been identified in the several plant families.The pharmacological properties of interest involving the sesquiterpene lactones are their antibacterial, antifungal and anti-plusmodial activities.Indeed, assessing the biological activities of the sesquiterpene lactones found in plants and th...