In mammals, daily rhythms in behaviour and physiology are driven by a circadian timing system comprised, in a hierarchical way, of a master pacemaker in the suprachiasmatic nuclei (SCN) of the hypothalamus and of peripheral oscillators in most body cells. At the molecular level, in both the SCN and peripheral oscillators, the circadian clock mechanism is built from interconnected feedback loops...

Achieving optimal production cycle time for improving manufacturing processes is one of the common problems in production planning. During recent years, different approaches have been developed for solving this problem, but most of them assume that mean quality characteristic is constant over production run length and sets it on customer’s target value. However, the process mean may drift from ...

Poor adhesion between two successive bituminous layers causes adverse effects on the structural strength of the pavement and develops a numbers of premature failure. To improve the adhesion, it is a general practice to apply a tack coat over an existing or newly constructed bituminous surface before laying another bituminous layer. The main objective of this study is to explore the influence of...

Local bus network is the most popular transit mode and the only available transit mode in the majority of cities of the world. Increasing the utility of this mode which increases its share from urban trips is an important goal for city planners. Timetable setting as the second component of bus network design problem (network route design timetable setting vehicle assignment crew assignment) hav...

poor adhesion between two successive bituminous layers causes adverse effects on the structural strength of the pavement and develops a numbers of premature failure. to improve the adhesion, it is a general practice to apply a tack coat over an existing or newly constructed bituminous surface before laying another bituminous layer. the main objective of this study is to explore the influence of...