objective(s): neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (tbi). two of these peptides are including the regulatory peptides neuromedin u (nmu) and neuromedin s (nms), and their common receptor neuromedin u2 receptor (nmur2). this study investigates the effects of physiological do...

introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

introduction: timely diagnosis and treatment of post traumatic, elevated intracranial pressure (eicp), could reduce morbidity and mortality, as well as improve patients’ outcome. this study is trying to evaluate the diagnostic accuracy of sonographic optic nerve sheath diameter (onsd) in detection of eicp. methods: sonographic onsd of patients with head trauma or cerebrovascular accident suspic...

Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the pathophysiology of this injury, this has not yet led to substantial improvements in outcome. In this report, we address present knowledge and its limitations, research innovations, and clinical implications. Improved outcomes for patients with severe traumat...

traumatic brain injury (tbi) is one of the major causes of severe disability and death in the entire world that accidents are mentioned as main factors of it. tbi lead to primary and secondary injuries.  primary injuries are created immediately after accidents or bleeding but the secondary injuries are created by complicated process of cellular and molecular responses following primary injury a...

INTRODUCTION Patients with severe traumatic brain injury are at a risk of developing ventilator-associated pneumonia. The aim of this study was to describe the incidence, etiology, risk factors for development of ventilator-associated pneumonia and outcome in patients with severe traumatic brain injury. MATERIAL AND METHODS A retrospective study was done in 72 patients with severe traumatic b...

objective: to investigate the effects of intracranial pressure (icp) monitoring on mortality rate and functional outcome of patients with severe traumatic brain injury (tbi). methods: this was historical cohort study being performed in nemazee hospital of shiraz during a 4-year period (from 2006 to 2010) including those patients with severe tbi who had undergone care based on icp monitoring (ca...

background: cerebral vasospasm is a preventable cause of death and disability in patients who experience aneurysmal subarachnoid hemorrhage (sah). the aim of this study is to investigate the incidence of cerebral vasospasm following traumatic sah and its relationship with different brain injuries and severity of trauma. method s: this cross-sectional study was conducted from october 2006 to mar...

Abstract Objective Despite the strong evidence suggesting post-traumatic stress disorder (PTSD) symptoms negatively impact cognition following mild traumatic brain injury (TBI), little is known about this relationship in more severe TBI. This study investigates between PTSD and cognitive performance complicated mild, moderate, severe, penetrating Methods Participants were 137 U.S. military serv...