Mechanical stimulation regulates endothelial cell (EC) functions through the modulation of signaling networks and gene expression. Our recent studies have identified that shear stress regulation of microRNAs (miRs)-19a, 23b and 27b, led to the modulation of EC proliferation. However, the underlying molecular mechanisms by which shear stress regulates these miRs have not been explored. Previous ...

local site conditions have a strong effect on ground response during earthquakes. two important soil parameters that control the amplification effects of seismic motions by a soil column are the soil hysteretic damping ratio and shear wave velocity. this paper presents the results of in situ damping ratio measurements performed using continuous surface wave attenuation data at a site in semnan ...

2014 It is shown, that shear flow destabilizes the planar texture of cholesterics of pitch small compared to sample thickness above a threshold shear rate. In addition, in the presence of the shear, perturbations of the planar configuration propagate with a velocity proportional to the shear rate. In this paper we present a simplified theory of these effects and compare our results with experim...

Shear rate can elicit substantial adaptations to vascular endothelial function. Recent studies indicate that prior exposure to anterograde flow and shear increases endothelium-dependent flow-mediated dilation at rest and that anterograde shear can create an anti-atherosclerotic and provasodilatory state. The primary aim of the present study was therefore to determine the effects of prior exposu...

We study the effects of ellipticity in lens galaxies and external tidal shear from neighboring objects on the statistics of strong gravitational lenses. For isothermal lens galaxies normalized so that the Einstein radius is independent of ellipticity and shear, ellipticity reduces the lensing cross section slightly, and shear leaves it unchanged. Ellipticity and shear can significantly enhance ...

an important concern in rock mechanics is non-homogeneity as joints or fault. adopting the joints as fractures, fractures are well known for their effects on the mechanical and transport properties of rock. it has been postulated that through fractured/jointed rock, mainly, the polygons turned to the shear vector (ti) are involved in the mobilization of shear resistance. consequently, in order ...

As gravitational lensing measurements become increasingly precise, it becomes necessary to include ever higher order effects in the theoretical calculations. Here we show how the difference between the shear and the reduced shear manifest themselves in a number of commonly used measures of shear power. If we are to reap the science rewards of future, high precision measurements of cosmic shear ...

An analysis of the effects of the turbulent shear stress on cell culture in a stirred tank microcarrier bioreactor system using a synergistic combination of computational fluid dynamic (CFD)-based simulations and experiments is presented. A 3D computational model of Corning’s benchscale spinner flask was built using a state-of-the-art computational fluid dynamics (CFD) software, Flow3D (www.flo...

in this paper, thermo-elastic analysis of a rotating thick truncated conical shell subjected to the temperature gradient, internal pressure and external pressure is presented. given the existence of shear stress in the conical shell due to thickness change along the axial direction, the governing equations are obtained based on first-order shear deformation theory (fsdt). these equations are so...

Geometric and material nonlinear behavior of slender webs in I-column girders having stocky flanges under the action of combined lateral and axial loads is investigated. Interaction curves corresponding to the application of compressive and shear loads at buckling and ultimate stages for both web plates and column sections are plotted. In addition, the effects of flange and web slenderness rati...