BackgroundNasal polyposis (NP) is an inflammatory condition in nasal and paranasal sinus cavities its pathophysiology poorly understood. It seems likely that the trace elements such as zinc selenium may play a critical role genesis of sinonasal disease.ObjectivesThe aim this study was to investigate these NP compare findings with normal mucosa.Methods & materialsIn descriptive-analytic cross-se...

Mounting evidence suggests that nasal polyposis (NP) is a clinical manifestation of multiple possibly coexisting immunologic pathways, and because this entity likely reflects an array of disease states, the epidemiology is difficult to characterize. Phenotypically, chronic rhinosinusitis (CRS) can be classified as either CRS without NP or CRS with NP. CRS without NP, in general, reflects TH1-me...

Amelonotic malignant melanoma; Sinonasal cavity; Nasal polyposis; Immunocytochemistry Abstract Malignant melanoma involving mucosal surface of the head and neck region is rare. Malignant melanoma involving the nasal cavity is even rarer and accounts for less than 1% of cases. Prognosis is generally poor with unpredictable outcome. Regional and distant metastasis is common at presentation. We pr...

OBJECTIVES/HYPOTHESIS Associations between olfactory function to quality-of-life (QOL) and disease severity in patients with rhinosinusitis is poorly understood. We sought to evaluate and compare olfactory function between subgroups of patients with rhinosinusitis using the Brief Smell Identification Test (B-SIT). STUDY DESIGN Cross-sectional evaluation of a multicenter cohort. METHODS Pati...

This article focuses on the tools that are available to assess nasal airflow, their utility in clinical practice, and comparison between them. Assessment of the nasal airway traditionally relied on history and physical examination only. Recently, tools have been developed that aid the physician in completing an assessment by measurement of parameters that are directly or indirectly related to a...

BACKGROUND Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population, with an estimated incidence of 1:2500 to 1:3000 among newborns. In patients with CF, there is a defect in chloride ion transport resulting in a reduction in the water content of secretions. The more viscous mucus impairs normal mucociliary patterns and causes mechanical obstruction of the...