This study compared reconstruction algorithms [filtered back projection (FBP) and simultaneous iterative reconstruction technique (SIRT)] with respect to radiation doses and image quality and suggested the possibility of decreasing the exposure dose in digital breast tomosynthesis (DBT). These two existing algorithms were implemented using a DBT system and experimentally evaluated using contras...

PURPOSE Selective internal radiation therapy (SIRT) is an effective treatment strategy for unresectable hepatocellular carcinoma (HCC) patients. However, the prognoses of patients with portal vein thrombosis, extra-hepatic metastases, or residual tumors remain poor when treated with SIRT alone. In these patients, sequential external beam radiotherapy (EBRT) may offer a chance of salvage. Here, ...

Image-guided interstitial brachytherapy is used for the treatment of primary and secondary liver tumors. Millions of nonbiodegradable yttrium-90 (90Y)-imprinted microspheres with a diameter of 29– 35 μmare selectively infused by a catheter into the branch of the hepatic artery supplying the tumor. Thereby, a radiation dose of 30–60Gy can be applied to the tumor tissue. 90Y is a beta-emitter wit...

BACKGROUND Many patients with primary liver cancers are not candidates for surgery, and systemic therapies are seldom effective. Selective internal radiation therapy (SIRT) has been shown to obtain partial and even complete response in unresectable primary tumors. As a "side effect", SIRT can induce contra-lateral liver hypertrophy. Tumor response to SIRT can be sufficient to allow disengagemen...

Recently, a survey by the Centers for Disease Control and Prevention (CDC) reported that nearly 90% of U.S. adult smokers began smoking at the age of 18. This demonstrates that the exposure to environmental tobacco smoke (ETS) of youngsters today is changing from passive smoking to active smoking (direct inhalation of tobacco). In the current study, an investigation of ETS exposure in young C57...

Selective internal radiation therapy (SIRT) is a promising treatment modality for advanced hepatocellular carcinoma or metastatic liver cancer. SIRT is usually well tolerated. However, in most patients, SIRT will result in a (temporary) decreased liver function. Occasionally patients develop radioembolization-induced liver disease (REILD). In case of a high tumor burden of the liver, it could b...