Fragile X syndrome (FXS) is characterised by hyper-reactivity, autistic tendencies and social anxiety. It has been hypothesised that the FXS social phenotype is secondary to a generalised hyper-reactivity that leads to social avoidance. No study, however, has investigated whether hyperarousal in FXS is generalised or more specific to socially salient information. We recorded skin conductance re...

Cancer is a disease that overwhelms the body with harmful and excessive cellular growth. There deadly accessory of stage IV cancer; Staphylococcus aureus disease-serving bacterium can infiltrate tumor microenvironment to support malignancy. Furthermore, immune tolerance acquired as bacteria-infested cancerous mass forms collagen-reinforced extracellular matrix. The review discusses allergy-assi...

we present some connections between the max-min general fuzzy automaton theory and the hyper structure theory. first, we introduce a hyper bck-algebra induced by a max-min general fuzzy automaton. then, we study the properties of this hyper bck-algebra. particularly, some theorems and results for hyper bck-algebra are proved. for example, it is shown that this structure consists of different ty...

Postinflammatory hyperpigmentation (PIH) is a common problem after cosmetic procedures and successful treatment of PIH remains challenging. We report the case of a 33-year-old man who presented with hyper-pigmented skin lesions on his legs that persisted for 6 months following laser hair removal. We used a 1,927-nm thulium fiber laser to treat the lesions, resulting in near complete resolution ...

Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. Thes...

The hyperimmunoglobulin E syndrome is a rare complex primary immunodeficiency characterized by high serum IgE levels, eczema, and recurrent infections. We present a case of 2-years-old girl with eczema and repeated bacterial skin and lung infections since the period of infancy. The patient also had eosinophilia, high serum levels of IgE, and cows-milk hypersensitivity. We describe the case, in ...

Introduction Hyper-IgD with periodic fever syndrome (HIDS) is an autoinflammatory disease characterized by periodic episodes of fever, abdominal distress, joint pain, and skin rashes. IL-1 blockade was previously reported as effective in reducing the frequency of episodes and improving clinical symptoms.[,] We report the results of the study assessing the efficacy and safety of canakinumab, an ...

An uncommon coexistence of circumscribed hyperpigmentation and hypopigmentation, in close proximity to each other, is described in a 17 years old patient with various other cogenital defects, such as dysmorphic facial appearance, severe kyphoscoliosis, delayed motor development, epileptic seizures, and mental retardation. We suggest the combination of hyper- and hypopigmented cutaneous lesions ...

Pityriasis versicolor is a common superficial fungal infection of the skin which is caused by various species of yeast of the genus Malassezia and is clinically characterized by scaly hypo pigmented or hyper pigmented macules usually involving the upper trunk, upper arms, neck and abdomen [1]. Lesions of pityriasis versicolor confined to face has rarely been reported. In this article the author...