Controlling beryllium inhalation exposures to comply with regulatory levels (2 micro g m(-3) of air) does not appear to prevent beryllium sensitization and chronic beryllium disease (CBD). Additionally, it has proven difficult to establish a clear inhalation exposure-response relationship for beryllium sensitization and CBD. Thus, skin may be an important route of exposure that leads to berylli...

Background The Multi-Organ-Chip (MOC) is a new micro size bioreactor. It offers two tissue cultivation segments (e.g. skin model, liver cells), which are connected by a dynamic micro pump system. [1,2] One future application of this system is the dermal application of substances for drug testing in vitro. In this study a method to simulate and validate the permeation of fluorescein sodium salt ...

Blood flow in microcirculation has found vital role in maintenance of body temperature. Its measurement is vital in the field of skin-vessel reactivity, ageing of skin, micro vascular repair of the ulnar artery and wound healing in association with total elbow replacement. The existing techniques for blood flow measurements like Electromagnetic blood flow measurement, Thermal convection method,...

We report a case of skin and soft tissue infection, peritonitis and bacteriemia in a 51-year-old drug abuse male. His wife found him lifeless lying on the kitchen floor at his residence. At the time of autopsy, multiple skin ulcers with deep soft tissue infection and peritonitis were found on gross examination. Cultures of postmortem blood and a swab of soft tissue were positive for Shewanella ...

BACKGROUND The yeast forms of Blastomyces dermatitidis usually range from 8 to 15-20 micro m in diameter. Larger yeast forms have previously been reported only twice in immunosuppressed patients. In both patients these large forms were seen within the lung. CASE REPORT We present a 14-year-old cardiac transplant patient, who presented 36 days following his transplantation with acute respirato...

Metal patch test is often used in clinical settings when metal-induced contact dermatitis is suspected. However, the transdermal permeation behavior of metal ions from the patch test remains unclear. Current patch tests using high concentrations of metal salt solutions have some side effects, e.g. acute skin reactions to high concentrations of metal salt. To resolve these, estimating metal ion ...

Atopic dermatitis (AD) is a common inflammatory skin disorder and characterized by abnormalities in both skin barrier structures and alternations of the immune response. Molecular genetics have dramatically changed our vision of the micro-organisms colonizing the human skin and recently well-documented changes in the skin microbiome in atopic dermatitis have become evident. The microbiome shift...

One of the effects of make-up cosmetics is directing skin beautifully by various skin textures. Differences in the impression of skin originates in their micro-geometric structures. To investigate the relation of the structure of skin and the impression, we are developing a system to simulate microstructure of human skins applying a 3D modeling technique. This paper reports a technique of input...

Wrinkle simulation with skin modeling and deformation are extremely important in enhancing the realism of human figure models. In this paper we present a model which simulates the skin deformation based on a biomechanic model and generates dynamic wrinkles rendered with texture image. The biomechanical model considers the skin as a membrane undergoing large deformations and puts the local coord...

Ratio blends of PLGA/PCL: (0:10), (1:9), (2:8), (3:7), (4:6), (5:5), (6:4), (7:3), (8:2), (9:1), and (10:0) were spin-coated to produce thin films; surface topographies were determined using interferometric microscopy. It was demonstrated that micro-wells of a defined size (150 mm) were present in all PCL dominant PLGA/PCL systems. Stratification of PLGA with PCL enabled the formation of that s...