نتایج جستجو برای: skin sensitization
تعداد نتایج: 208578 فیلتر نتایج به سال:
BACKGROUND The thinness of the periorbital skin may facilitate allergen penetration, making this area particularly susceptible to sensitization. MATERIAL AND METHODS For the cross-sectional study, data were collected by the 57 participating centres of the Information Network of Departments of Dermatology. A total of 101 403 patients patch tested between January 2001 and December 2010 were inc...
Background Skin Prick Testing has long been considered the standard for detecting sensitization to inhalent Allergens. However, in vitro testing for specific IgE is also common practice. Various studies have shown that these two methods are equal in sensitivity and specificity, while others have indicated that in vitro testing is less sensitive. This study was performed to compare in vitro Immu...
Secondary Hyperalgesia Phenotypes Exhibit Differences in Brain Activation during Noxious Stimulation
Noxious stimulation of the skin with either chemical, electrical or heat stimuli leads to the development of primary hyperalgesia at the site of injury, and to secondary hyperalgesia in normal skin surrounding the injury. Secondary hyperalgesia is inducible in most individuals and is attributed to central neuronal sensitization. Some individuals develop large areas of secondary hyperalgesia (hi...
Consumer safety risk assessment of skin sensitization requires information on both consumer exposure to the ingredient through product use and the hazardous properties of the ingredient. Significant progress has been made in determining the hazard potential of ingredients without animal testing. However, hazard identification is insufficient for risk assessment, and an understanding of the dose...
BACKGROUND Observational evidence suggests that infection with helminths protects against allergic disease and allergen skin sensitization. It is postulated that such effects are mediated by helminth-induced cytokine responses, in particular IL-10. OBJECTIVE We tested this hypothesis in a rural area of central Vietnam where hookworm infection is endemic. METHODS One thousand five hundred an...
BACKGROUND The major house dust mite allergen Der p 2 is a structural and functional homologue of MD-2 within the TLR4-CD14-MD-2 complex. An asthma mouse model in TLR4-deficient mice recently suggested that the allergic immune response against Der p 2 is solely dependent on TLR4 signaling. We investigated whether similar mechanisms are important for Der p 2 sensitization via the skin. METHODS...
PURPOSE Inhalant allergen sensitization is one of the major factors involved in the pathogenesis of allergic respiratory diseases. However, the sensitization is determined by interactions between genetic and environmental factors. Thus, testing panels of inhalant allergens may differ among geographical areas. Here we aimed to determine 10 common inhalant allergens in Korean adult patients with ...
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