UNLABELLED Solar radiation causes damage to human skin, and photoprotection is the main way to prevent these harmful effects. The development of sunscreen formulations containing nanosystems is of great interest in the pharmaceutical and cosmetic industries because of the many potential benefits. This study aimed to develop and evaluate an octyl methoxycinnamate (OMC) liposomal nanosystem (lipo...

the purpose of this study is determining of some immunity and blood serum parameters in brood stock and grower fish before and after of stripping to evaluate the effect of breeding physiological changes on immunity and serum indexes. in this study 15 male trout fish (oncorhynchus mykiss) including 5 in the stage of grower, 5 before stripping and 5 after stripping randomly were considered. blood...

Dead Sea therapy is one of the oldest forms of treatment for skin disease and some chronic inflammatory diseases like arthritis and psoriasis. Much of the research to date has attributed the clinical effects of Dead Sea therapy to its mineral composition; mostly to magnesium salts. Magnesium salts, such as magnesium sulphate (Epsom salts), have long been used as a spa product and as a therapeut...

Langerhans cells and dermal dendritic cells migrate to the draining lymph nodes through dermal lymphatic vessels. They do so in the steady-state and under inflammatory conditions. Peripheral T cell tolerance or T cell priming, respectively, are the consequences of migration. The nature of dendritic cell-containing vessels was mostly defined by electron microscopy or by their lack of blood endot...

OBJECTIVES Although corticosteroids have been used for over 50 years as anti-inflammatory and anti-proliferative agents, few studies have examined their exposure levels and health effects on workers employed in the corticosteroid manufacturing industry. The aims of the study reported here were to develop a tape-stripping technique for monitoring budesonide (a corticosteroid used in inhalators f...

Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, well established mechanisms for However, large scale data acquisition is a problem it relies mostly on invasive biopsies. Here we present method non-invasive sample collection using tape-stripping analysis. We compared matched shave biopsies tape stripping samples to...

Summary Using cryogenic transmission electron microscopy, we revealed three-dimensional (3D) structural details of the electrochemically plated lithium (Li) flakes and their solid electrolyte interphase (SEI). As SEI skin layer is largely composed nanocrystalline LiF Li2O in amorphous polymeric matrix, when complete Li stripping occurs, compromised 3D framework buckles wrink...

P. Bindi, Service de Néphrologie, (Prof. Mignon), Hôpital Tenon, 4, rue de la Chine, F-75020 Paris (France) Dear Sir, Aluminum (Al) overload is still a worrying problem in long-term dialysis patients. Data are lacking on Al accumulation in the skin of such patients and its relationship to bone overload. Skin biopsies would yet be a noninva-sive method to assess Al intoxication. In their study, ...

Pharmaceuticals and cosmetics for dermal application are usually tested on healthy skin, although the primary permeation barrier, the stratum corneum, is often impaired by skin diseases or small skin lesions, especially on the hands. These skin conditions can considerably influence the permeation of chemicals and drugs. Furthermore, risk assessment for example of nanoparticles should be perform...

The objective of the current study was to formulate ketorolac tromethamine-loaded elastic liposomes and evaluate their in vitro drug release and their ex vivo and in vivo transdermal delivery. Ketorolac tromethamine (KT), which is a potent analgesic, was formulated in elastic liposomes using Tween 80 as an edge activator. The elastic vesicles were prepared by film hydration after optimizing the...