BACKGROUND In the field of Plastic Reconstructive Surgery the development of new innovative matrices for skin repair is in urgent need. The ideal biomaterial should promote attachment, proliferation and growth of cells. Additionally, it should degrade in an appropriate time period without releasing harmful substances, but not exert a pathological immune response. Spider dragline silk from Nephi...

Skin plays an important role in defense against infection and other harmful biological agents. Due to its fragile structure, skin can be easily damaged by heat, chemicals, traumatic injuries and diseases. An autologous bilayered human skin equivalent, MyDerm™, was engineered to provide a living skin substitute to treat critical skin loss. However, one of the disadvantages of living skin substit...

Aim: Extensive or irreversible damage to the skin often requires additional skin substitutes for reconstruction. Biomaterials have become critical components in the development of effective new medical therapies for wound care. Materials and Methods: In the present study, a cell matrix construct (bone marrow-derived cells (BMdc) seeded extracellular matrix [ECM]) was used as a biological substi...

INTRODUCTION Bioresorbable polymers are often used in medical procedures. Since they are biocompatible, this class of materials is a viable alternative for cases in which tissue regeneration is strongly compromised. Bioresorbable synthetic polymers may be used as membranes to support and guide cell growth through the process of tissue repair. OBJECTIVE To assess the efficiency of a porous bio...

BACKGROUND Dermal skin substitutes have become a standard of care in burn treatment. OBJECTIVE To compare and assess wound contracture reduction and histologic incorporation into the wound, dermal substitutes were implanted into full-thickness skin wounds in nude mice. MATERIALS AND METHODS Thirty-seven mice received a full-thickness 2 x 2 cm dorsal skin wound, and were either implanted wit...

Gelatin and collagen were used to produce the scaffold for fibroblast cell culture. The properties of scaffolds obtained from type A and type B gelatin were compared to scaffold obtained from collagen, which is widely used in skin substitute. Porous scaffolds were prepared by freeze drying and dehydrothermal (DHT) crosslinking method. DHT treatment time was performed at 24 and 48 h and the degr...

Acid-soluble collagen could be isolated from fish skin using acetic acid. In recent years, much attention has been paid to collagen from marine sources, mainly arising from the fact that there is no risk of contagious diseases. Moreover, by processing the fish, significant amounts of waste materials are produced which can be considered as a substitute for these collagen sources. Thunnus tonggol...