نتایج جستجو برای: slc30a8
تعداد نتایج: 228 فیلتر نتایج به سال:
OBJECTIVE Evaluate type 2 diabetes susceptibility variants identified from genome-wide association studies in Hispanic Americans and African Americans from the Insulin Resistance Atherosclerosis Family Study (IRAS-FS) for association with quantitative measures of glucose homeostasis and determine their biological role in vivo. RESEARCH DESIGN AND METHODS Seventeen type 2 diabetes-associated s...
BACKGROUND Recently, several Genome Wide Association (GWA) studies in populations of European descent have identified and validated novel single nucleotide polymorphisms (SNPs), highly associated with type 2 diabetes (T2D). Our aims were to validate these markers in other European and non-European populations, then to assess their combined effect in a large French study comparing T2D and normal...
Association Between SLC30A8 Gene rs3802177 Polymorphism and T2DM in Asian Population-a Meta-Analysis
Impaired insulin sensitivity and reduced b-cell function have been regarded as the two major physiological defects in type 2 diabetes mellitus. It is generally accepted that the initial defect in this disease is insulin resistance, which is typically elicited by overeating and decreased physical activity, both of which are tightly linked with obesity. b-Cells then compensate for insulin resista...
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