OBJECTIVE Neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) originate from immune-mediated disease (primary neuropsychiatric SLE) or from other pathogenetic mechanisms indirectly related to SLE (secondary neuropsychiatric SLE). The objective of this study is to describe the clinical practice of diagnosing NP-SLE and to assess how often the diagnosis of primary ...

objective: reports of increased level of myeloperoxidase (mpo) in plasma and placental extracts of systematic lupus erythematosus (sle) has been proposed that mpo may have an important role in this pregnancy complication. in present study immunohistochemical mpo expression was investigated in placental samples of sle women compared with normal controls. materials and methods: ten patients with ...

background: systemic lupus erythematosus (sle) is a chronic autoimmune disease which is characterized by b-cell abnormality and auto-antibody generation. since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with sle. objective: to investigate humoral immunity and specific-antibody formation in response to a...

SUMMARY Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens. The aim was to detect sets of antibody reactivities characteristic of SLE patients in each of various clinical states--SLE patients with acute lupus nephri...

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) has been considered as an immunomodulatory factor. Objective: To investigate the effect of 1,25VitD3...

Background: Considering the role of Duffy antigenic system expression on RBCs as chemokines for inflammatory cytokines, expression of Duffy antigens as different phenotypes was studied in a group of patients with SLE. The association between different phenotypes of Duffy antigens and occurrence of SLE and its severity was assessed.  Methods: This cross-sectional study was carried out on 100 pa...

how to cite this article: shiari r, hassase yegane m, farivar s, javadi parvaneh v, mirjavadi sa. neuropsychiatric symptoms as the first manifestation of juvenile systemic lupus erythematosus: a complicated case with klinefelter’s syndrome. iran j child neurol. 2014 winter; 8(1):62-65. abstract systemic lupus erythematosus (sle) is an autoimmune, multisystem disorder with various manifestations...

manifestation of chorea in patients with systemic lupus erythematosus (sle) and antiphospholipid antibody syndrome (apa synd.) is not common. moreover, primary presentation of the disease with chorea is rare and only few such cases are reported in literature in recent years. we report here the case of a 28 year old woman who was first seen at the age of 10 with clinical manifestations of chorea...

OBJECTIVE Infection is a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). Therapeutic practices have evolved over the past 15 years, but effects on infectious complications of SLE are unknown. We evaluated trends in hospitalizations for severe and opportunistic infections in a population-based SLE study. METHODS Data derive from the 2000 to 2011 United States Na...