BACKGROUND Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. Our goal was to evaluate the role of vascular smooth muscle SirT1 in the physiological response of the aortic wall to angiot...

ketotifen is a benzocycloheptathiophene with a range of pharmacological activities. the present study was carried out to evaluate the action of ketotifen on isolated rat bladder contractions induced by kci and acetylcholine, compared with the effects of other drugs. ketotifen (5 µm) reduced the response to acetylcholine on rat isolated bladder without altering the maximum response and shifted t...

We have developed a self-consistent model for predicting the velocity of 1/2[111] screw dislocation in binary iron–carbon alloys gliding by high-temperature Peierls mechanism. The methodology modelling includes: (i) Kinetic Monte-Carlo (kMC) simulation carbon segregation core and determination total occupancy binding sites; (ii) Determination kink-pair formation enthalpy iron—carbon alloy; (iii...

The problem of disorder seeks to determine a stopping time which is as close as possible to the unknown time of ’disorder’ when the observed process changes its probability characteristics. We give a partial answer to this question for some special cases of Lévy processes and present a complete solution of the Bayesian and variational problem for a compound Poisson process with exponential jump...

The yielding behavior of a sheared Laponite suspension is investigated within a 1 mm gap under two different boundary conditions. No-slip conditions, ensured by using rough walls, lead to shear localization as already reported in various soft glassy materials. When apparent wall slip is allowed using a smooth geometry, the sample breaks up into macroscopic solid pieces that get slowly eroded by...

Elastic rods are curve-like elastic bodies that have one dimension (length) much larger than the others (cross-section). Their elastic energy breaks down into three contributions: stretching, bending, and twisting. Stretching and bending are captured by the deformation of a space curve called the centerline, while twisting is captured by the rotation of a material frame associated to each point...

purpose : the aim of this study was to compare the rate and location of intraoperatively induced retinal breaks between two techniques of standard 20-gauge vitrectomy and transconjunctival 23-gauge using trocar/cannula methods : in this prospective comparative case series patients having attached retina before surgery who were operated for different vitreoretinal or macular conditions by standa...

An alternative pathway for the initiation of dewetting in thin metastable films of partially miscible liquid mixtures is described. In this pathway, phase separation is followed by a dewetting process at the interface between the two phases. Dewetting proceeds (from the sample edges inward) as holes form. The initially smooth film breaks up into droplets at rates much faster than those allowed ...

This paper offers a way to construct a locally optimal stationary approximation for a non-stationary Gaussian process. In cases where this construction leads to a unique stationary approximation we call it a stationary tangent. This is the case with Gaussian processes governed by smooth n-dimensional correlations. We associate these correlations with equivalence classes of curves in R. These ar...

One of the fundamental facts in control theory (Artstein’s theorem) is the equivalence, for systems affine in controls, between continuous feedback stabilizability to an equilibrium and the existence of smooth control Lyapunov functions. This equivalence breaks down for general nonlinear systems, not affine in controls. One of the main results in this paper establishes that the existence of smo...