Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is associated with worse outcomes. The combination of ledipasvir (LDV) and sofosbuvir (SOF) has been approved for HCV treatment after LT, but there are limited data on the effectiveness and safety of LDV/SOF in the "real-world" setting. This multicenter study is the largest report to date on the effectiveness and safety of LDV/...

Blastocyst formation, as a critical period during development, is an effective indicator of embryonic health and reproductive efficiency. Out of a number of mechanisms underlying blastocyst formation, highly conserved mitogen-activated protein kinase (MAPK) signaling has emerged as a major mechanism involved in regulating murine preimplantation embryo development. The objective of our study was...

Background: Treatment of hepatitis C virus (HCV) infection with recently introduced direct-acting antiviral agents (DAA) is effective and safe, however there is little known regarding safety and efficacy of generic DAAs in the real-life clinical setting. This study aimed to evaluate the efficacy and safety of generic sofosbuvir/ledipasvir (SOF/LDV) in a real-life clinical experience. Methods: ...

Abstract— This paper is concerned with the problem of H∞ static output feedback (SOF) control of two-dimensional (2-D) discrete systems described by the Roesser model. By applying the 2-D Bounded Real Lemma, a design criterion for the 2D H∞ SOF controller is derived. Since the existence condition for the SOF controller is not expressed strictly in terms of linear matrix inequalities (LMIs), the...

Hepatitis C virus (HCV) infection affects roughly 170 million people worldwide. Sofosbuvir/Ledipasvir (Sof/Led) is a new once daily direct acting antiviral combination pill that was approved in October 2014 for use in patients with HCV genotype 1 infection. Coadministration of Sof/Led is studied only with rosuvastatin which shows significantly increased level of drug and is associated with incr...

This paper is concerned with the static output feedback (SOF) stabilization for discrete-time networked control systems (NCSs) with input and output signals quantization. A novel model of the systems is proposed by a sector bounded approach where the internal effects of network induced delay and signals quantization are considered. By using Lyapunov functional approach, together with introducin...

OBJECTIVE To assess the current state of reporting of pain outcomes in Cochrane reviews on chronic musculoskeletal painful conditions and to elicit opinions of patients, healthcare practitioners, and methodologists on presenting pain outcomes to patients, clinicians, and policymakers. METHODS We identified all reviews in the Cochrane Library of chronic musculoskeletal pain conditions from Coc...

Figure 1.NEUTRINO study design. OFood and Drug Administration (FDA) approvedsofosbuvir (SOF) for the treatment of chronic hepatitis C (CHC) viral infection as a component of an antiviral treatment regimen. SOF is an inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase and inhibits HCV replication. SOF was designated a breakthrough therapy because preliminary clinical evide...

Background: The objective of the current study was to determine the effect of activation of injected oocytes with dithiothreitol on development of ovine embryos derived from in vitro-matured oocytes and intracytoplasmic sperm.The injected oocytes with non-treated sperm were activated with 1) ionomycin (Io) + 6-dimethylaminopurine (6-DMAP) 2) DTT, 3) DTT+ ionomycin (I)+6-DMAP. Materials and Meth...

BACKGROUND Eradication of hepatitis C virus (HCV) using direct-acting agents (DAA) has been associated with a financial burden to health authorities worldwide. We aimed to evaluate the guideline-based treatment costs by DAAs from the perspective of the Brazilian Ministry of Health (BMoH). METHODS The activity based costing method was used to estimate the cost for monitoring/treatment of genot...