Lipid nanoparticles of the cancer drug Chlorambucil (CLB) were prepared by ultrasonication, using stearic acid as the core lipid. Four types of lipid nanoparticle formulations were studied: (i) stearic acid solid lipid nanoparticles (SLN); (ii) sterically stabilized SLN with pegylated phospholipids as stabilizer; (iii) nanostructured lipid complexes with oleic acid as adjunct lipid; (iv) lipid ...

The present work proposes a unique de-PEGylation strategy for controllable delivery of small interfering RNA (siRNA) using a robust lipid-polymer hybrid nanoparticle (NP) platform. The self-assembled hybrid NPs are composed of a lipid-poly(ethylene glycol) (lipid-PEG) shell and a polymer/cationic lipid solid core, wherein the lipid-PEG molecules can gradually dissociate from NP surface in the p...

Nanotechnology has been extensively explored in the past decade to develop a myriad of functional nanostructures to facilitate the delivery of therapeutic and imaging agents for various medical applications. Liposomes and polymeric nanoparticles represent two primary delivery vehicles that are currently under investigation. While many advantages of these two particle platforms have been disclos...

Density-functional tight-binding molecular dynamics (DFTB/MD) methods were employed to demonstrate single-walled carbon nanotube (SWNT) nucleation resulting from thermal annealing of SiC nanoparticles. SWNT nucleation in this case is preceded by a change of the SiC structure from a crystalline one, to one in which silicon and carbon are segregated. This structural transformation ultimately resu...

The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films reveal their potential as successful drug formulations. SLNs based on (Lipoid S100) surfactant (polysorbate 80) were prepared using the solvent-injection method, properties examined experimental designs. Further, marker coumarin 6 (C6) solubilized in particles a model for lipophil...

topical retinoids are considered as the first line therapy in the treatment of acne vulgaris, but they are associated with cutaneous irritation. in this study, isotretinoin-loaded solid lipid nanoparticles(it-sln) were prepared to treat the mild to moderate acne. also using it-sln would minimize it adverse effects in comparison to commercial product, isotrex®. this study was conducted to prepar...