Some organic compounds form gels in liquids by forming a network of anisotropic fibres. Based on extensive solubility tests of four gelators of similar structures, and on Hansen solubility parameter formalism, we have probed the quantitative effect of a structural variation of the gelator structure on its gel formation ability. Increasing the length of an alkyl group of the gelator obviously re...

The aggregation and solubility of asphaltenes are studied by classical molecular dynamics simulations. Average three-dimensional atomistic models are built on the basis of experimental data for the asphaltenes from a series of crude oil samples. The simulation of two such asphaltene models in four different solvents puts into evidence the formation of oligomeric clusters and gives clues to the ...

The solubility of the spin label TEMPO (I) in membranes depends on the fluidity of the membrane. An empir ical relat ionship has been establ ished between TEMPO solubility and fluidity, measured by the order parameter S~o. This relationship is employed to determine the fract ion of the lipid in membranes of rabbit muscle sarcoplasmic re t iculum that is in a fluid state. We find that 84% of the...

In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were de...

The solubility of satranidazole in several water-N,N-dimethylformamide mixtures was analysed in terms of solute-solvent interactions and data were treated on the basis of extended Hildebrand solubility approach. The solubility profile of satranidazole in water-N,N-dimethylformamide mixtures shows a curve with a solubility maxima well above the ideal solubility of drug. This is attributed to sol...

The time-lag method, using a gas permeation experiment, is currently the most popular method for determining the membrane properties: diffusivity coefcient and permeability coefcient, and from which the solubility coefcient can be calculated. In this investigation, the impact of systematic, random (noise), resolution and extrapolation errors associated with gas permeatio...

The aim of this review was to improve the solubility and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. Solubility is one of the important parameter...

The aqueous solubility (logW) and n-octanol/water partition coefficient (logP(OW)) are important properties for pharmacology, toxicology and medicinal chemistry. Based on an understanding of the dissolution process, the frontier orbital interaction model was suggested in the present paper to describe the solvent-solute interactions of organohalogen compounds and a general three-parameter model ...