BACKGROUND Increased risks of nasal cancer and lung cancer in nickel refiners have been investigated scientifically and discussed since they were detected in the 1930s. Nickel compounds are considered to be the main cause of the cancer excess. Parts of the nickel producing industry and their consultants oppose the classification of water-soluble nickel salts as human carcinogens, and argue that...

People can ingest soluble nickel compounds as a normal constituent of food or as a contaminant in drinking water. This paper presents an assessment of the noncancer and cancer human health risks from ingestion of soluble nickel compounds. A reference dose (RfD) of 8 x 10(-3) mg Ni/kg/day in addition to the amount in food was calculated, based on albuminuria in female rats exposed to nickel sulf...

The soluble and ionized calcium and magnesium contents of 18 lots of Mueller-Hinton agar medium from three different manufacturers were analyzed, and the results were correlated with medium performance. A standardized disk diffusion test, with Pseudomonas aeruginosa (ATCC 27853) and a 10-microgram gentamicin disk, served as an indicator of medium performance. Zone diameters correlated well with...

Cases are admitted from time to time to most large hospitals in a state of coma or semi-coma in which the differential diagnosis includes overdosage with the barbiturate series of narcotic drugs. It is often important to confirm or exclude this factor as quickly as possible. Standard methods of analysis (e.g., the Stas-Otto process, Smith, 1934a), although ultimately giving accurate quantitativ...

The changes produced by the action of rennin in milk and solutions of casein have been the subject of many investigations. Fremy’ was probably the first to give an explanation of this phenomenon. He believed the power to coagulate milk possessed by an extract of the mucous lining of a calf’s stomach to be due to the presence of an enzyme which converted some of the lactose of the milk into lact...

A substantial body of occupational epidemiology data has shown that exposure to mixed soluble and insoluble nickel causes the development of lung and nasal cancer. However, due to coexposure of these populations to soluble and insoluble forms of nickel, and limitations in exposure measurements, the contribution of soluble nickel is difficult to determine. Soluble nickel was negative in an NTP i...

logical^ properties of fredericamycin A (FM-A, NSC-305263) a novel antitumor antibiotic produced by Streptomyces griseus (FCRC-48) were reported earlier. The structure (1) was elucidated by spectroscopic and X-ray techniques1'3'4) followed by its biosynthesis,5) electron spin resonance,6) and synthetic studies.n FM-Aexhibited good in vitro activity against Gram-positive bacteria, fungi and was ...