The solutions used to solve bi-level congestion pricing problems are usually based on heuristic network optimization methods which may not be able to find the best solution for these type of problems. The application of meta-heuristic methods can be seen as viable alternative solutions but so far, it has not received enough attention by researchers in this field. Therefore, the objective of thi...

Toll-like receptor 2 (TLR2) and TLR4 play important roles in innate immune responses to various microbial agents. We have previously shown that human dermal endothelial cells (HMEC) express TLR4, but very little TLR2, and respond to LPS, but not to Mycobacterium tuberculosis 19-kDa lipoprotein, unless transfected with TLR2. Here we report that HMEC are unresponsive to several additional biologi...

Stimulation of Toll-like receptor 2 (TLR2) on epidermal keratinocytes results in the tightening cell–cell junctions between keratinocytes; therefore, appropriate agonists for TLR2 could be promising ingredients cosmetics. However, a method to produce significant amounts soluble using materials that are suitable preparing cosmetics has not yet been developed. In this study, we tried identify lac...

background one-third of the world’s population is infected with mycobacterium tuberculosis. investigation of toll-like receptors (tlrs) has revealed new information regarding the immunopathogenesis of this disease. toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. toll-like receptor 2 and tlr-4 have been identified in association with tuberculosis in...

the importance of the role played by bacteria in the pathogenesis of pulpal and apical disease has been established. one of the characteristics of apical periodontitis is apical bone resorption, which is due to apical immune response to bacterial infection. recently, novel bacterial complex lipid called phosphorylated dihydroceramides has been discovered to be of inflammatory activators. the ba...

it has been suggested that single nucleotide polymorphisms (snps) in genes involved in toll-like receptors (tlrs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. however, the extent to which these variations affect tlr signaling is not well understood. in this study, we adopted a bioinformatics approach to predict the consequences...