This investigation was concerned with the acute effect of ethionine, thioacetamide, dimethylnitrosamine (DMN), or aflatoxin B, on hepatic polyribosomes and protein synthesis of rats fed purified diets either ad libitum for 3 to 29 weeks containing 0.025% N-2-fluorenylacetamide (2FAA) or 0.06% 3 -methyl-4-dimethylaminoazobenzene (3 Me-DAB) or by force-feeding for 3 days of diets containing 2-FAA...

There is a wealth of evidence from both epidemiological studies (Hales and Barker, 2001) and animal models (Tarry-Adkins and Ozanne, 2016) that environmental exposures during early mammalian development may alter developmental trajectories in a manner that results in altered disease susceptibility and stress responsiveness in later life. This phenomenology is termed 'developmental programming.'...

Usubuchi sarcoma (US) is one of the methyicholanthrene-induced ascites tumors in the rat. It was established in 1953 by transforming a solid type tumor into the ascites type (Usubuchi et al. 1953). Since then, the US has been main tained over 1900 transfer generations in his laboratory by successive transfers. The chromosome investigations of the US have been made in some early stages before th...

HANDLING human chromosomes is my métier. I meric constrictions). This pivotal discovery in a cell culture laboratory on the Gulf Coast of Texas in the early realized that long ago; however, preparing an article for Perspectives led me to ask myself how this 1950s—that immersion of mitotic cells in a hypotonic medium will make the chromosomes suitable for microcame to be. I, like others who took...

model building and other predictive structural analysis. The proposal made 25 years ago that chromatin struc-The histones came to be regarded as an amorphous ture is based on a repeating unit of eight histone mole-coating or passive polymeric counterion of the DNA. cules and about 200 DNA base pairs (Kornberg, 1974) Ironically, the very breakthrough of acid extraction, laid the basis for subseq...

The increase in interfollicular epidenmal nibosomes on the backs of mice initiated with 7,12-dimethylbenz(a)anthracene and promoted with 12-O-tetradecanoyl-phambol 13-acetate was disproportionate to the increase in epi dermal wet weight, protein, and DNA. Whereas mibosame numbers increased fiveto sixfold 48 hr after the first, fourth , or eighth application of 12-O-tetradecanoyl-pharbal 13-acet...