Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells. Salmonellae deploy effectors that trigger localized actin reorganization to force their own entry into non-phagocytic host cells. Six effectors (SipC, SipA, SopE/2, SopB, SptP) can individually manipulate actin dynamics at the plasma m...

Salmonella enterica serovar Heidelberg ranks among the most prevalent causes of human salmonellosis in the United States and Canada, although it has been infrequently reported in South American and European countries. Most Salmonella infections are self-limiting; however, some invasive infections require antimicrobial therapy. In this work we characterized an oxyimino-cephalosporin resistant S....

Recognition of conserved bacterial products by innate immune receptors leads to inflammatory responses that control pathogen spread but that can also result in pathology. Intestinal epithelial cells are exposed to bacterial products and therefore must prevent signaling through innate immune receptors to avoid pathology. However, enteric pathogens are able to stimulate intestinal inflammation. W...

Due to the increasing demand for cloud services and the threat of privacy invasion, the user is suggested to encrypt the data before it is outsourced to the remote server. The safe storage and efficient retrieval of d-dimensional data on an untrusted server has therefore crucial importance. The paper proposes a new encryption model which offers spatial order-preservation for d-dimensional data ...

Facing the many host defense mechanisms at different stages of the infection, a pathogen needs to employ corresponding arsenals either to hijack host cellular processes for its own use or to thwart the attacks from the host. For numerous bacterial pathogens, one of the effective weapons is effector protein. Type IV protein secretion systems are associated with the virulence of many important pa...