Local anaesthetics as a group possess spasmolytic effect on the smooth muscles (2). Uterine muscle though basically a smooth muscle organ, differs from other smooth muscle organs in many respects. Physiologically it is more under the control of sex hormones than the autonomic nervous system. There exists wide species variation in the responses to autonomic nervous stimulation. Pharmacologically...

The present study was designed to further evaluate a possible spasmolytic activity of synthetic lapachol derivatives, norlapachol, alpha-norlapachone, beta-norlapachone and hydro-hydroxy-norlapachol (HH-norlapachol), on guinea-pig ileum. In guinea-pig ileum, except for norlapachol, all naphthoquinones inhibited the phasic contractions induced by carbachol or histamine. Even when the ileum was p...

In continuation of our work on Indian celery (Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOH-H(2) O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cyt...

OBJECTIVE To evaluate whether it is feasible to measure the segmental flux of small bowel content using MR phase-contrast (PC) pulse sequences. MATERIALS AND METHODS Using a phantom the accuracy of flux measurements was validated. Afterwards, 10 volunteers were included in a prospective clinical trial. To provide standardized small bowel distension, all volunteers ingested four equal portions...

In vivo and in vitro research study was conducted on Cyperus rotundus to evaluate the sound mechanistic background in the treatment of gastrointestinal, bronchial and vascular disorders as well as in pain, emesis, pyrexia and bacterial infections. Results showed that crude extract of Cyperus rotundus (Cr.Cr) exhibited the dose-dependent spasmolytic effect in rabbit jejunum by inhibiting the spo...

The antispasmodic and spasmolytic effects of methanolic extract of seeds of Garcinia kola Heckel were studied on smooth muscle preparations in vitro. The influence of the extract on rat duodenum, jejunum and ileum was investigated using acetylcholine and barium chloride as agonists. The extract exhibited dose-dependent antispasmodic effects on contractions induced by acetylcholine, and dose-dep...

We investigated the spasmolytic activity of herbal drugs isolated from Tephrosia purpurea on guinea pigs for the treatment of asthma in India. For this investigation, the herbal drug was extracted with 70% ethanol in soxhlet apparatus. After purification and isolution, the drug was used in experimental animals to observe prophylactic activity. For anaphylactic activity, horse serum 0.5 ml along...