To conduct exposure-based assessments of possible noncancer or cancer health hazards from oral exposures to mixtures of 2,3,7,8-TCDD, hexachlorobenzene, p,p’-DDE, methylmercury, and PCBs, component-based approaches are recommended, because there are no direct data available to characterize health hazards (and dose-response relationships) from exposure to the mixture. In addition, PBPK/PD models...

BACKGROUND In medical research, one common competing risks situation is the study of different types of events, such as disease recurrence and death. We focused on that situation but considered death under two aspects: "expected death" and "excess death", the latter could be directly or indirectly associated with the disease. METHODS The excess hazard method allows estimating an excess mortal...

The critical infrastructures protection landscape is a vast and varied pattern of independent, but interconnected infrastructure systems that are essential to the function our modern society. U.S. policy on has be

Deterministic flood hazard estimates neglect the inherent uncertainty associated with model and can substantially underestimate risk. Monte Carlo simulation (MCS) has been a valuable tool for conducting analysis. However, its application primarily limited to single research setting. Recent development of point approximation method, simplified bounding (SUB), simulated from MCS high accuracy (e....

Come with us to read a new book that is coming recently. Yeah, this is a new coming book that many people really want to read will you be one of them? Of course, you should be. It will not make you feel so hard to enjoy your life. Even some people think that reading is a hard to do, you must be sure that you can do it. Hard will be felt when you have no ideas about what kind of book to read. Or...