Human infertility affects 10–15% of couples, half of which is attributed to the male partner. Abnormal spermatogenesis is a major cause of male infertility. Characterizing the genes involved in spermatogenesis is fundamental to understand the mechanisms underlying this biological process and in developing treatments for male infertility. Although many genes have been implicated in spermatogenes...

background: the global prevalence of diabetes mellitus is on rise. diabetes-induced oxidative stress has been known to affect liver, pancreas, kidney and reproductive organs pathologically. honey is a natural product of bee with antioxidant properties. objective: current study aimed to analyze the protective effects of metformin (mf) alone and mf+ natural honey co-administration on diabetes-ind...

Throughout spermatogenesis multiplication, maturation and differentiation of germ cells results in the formation of the male gamete. The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the structure and function of different types of germ cells, endocrine and paracrine cells and mechanisms, intratesticular and extratesticular regul...

THE EFFECT OF ALOE VERA HYDROALCOHOLIC EXTRACT ON SPERMATOGENESIS PARAMETERS AND HISTOLOGICAL CHANGES IN TESTIS RATS FED WITH A HIGH-FAT DIET

Epigenetic modifications change gene expression in such a way that gene action is affected without change in DNA sequence. Several genes playing crucial roles in spermatogenesis are known to be epigenetically regulated. Epigenetic modifications affect spermatogenesis, and aberrant epigenetic modifications at certain loci are linked to male infertility. Epigenetic modifications could be the mech...

Background: Varicocele is associated with impaired spermatogenesis. It may also be associated with the patients' weight. We aimed to determine the relationship between body mass index (BMI) and the frequency and grade of varicocele among a sample of Iranian men in southeast Iran. Methods: This cross-sectional study was conducted during 2010 and 2011 among 167 men who referred to the University ...

background: different investigation showed that 5-methoxypsoralen and 8- methoxypsoralen reduce birth rates in the rats. objective: in this study we worked out the effect of methoxsalen together with ultraviolent a (uva) radiation on mature balb/c mice spermatogenesis. materials and methods: the ld50 standard was determined 160 mg/kg and the uva dose which causes erythema was calculated 0.046 j...

background physical activity and alteration of temperature as a source of stress may have adverse effects on male reproduction. objectives the aim of this study was to investigate the effect of chronic swimming and standing in cold, warm and lukewarm water on mouse spermatogenesis. materials and methods forty-nine male mice (n = 49) were randomly divided into seven groups: c, control; swc, swim...