The cytotoxic activity of Adriamycin was examined in the MGHU1 human bladder carcinoma line, grown as monolayer culture, as spheroids, and as xenografts in immune-deprived mice. The MGH-U1 cells grown as spheroids were much more resistant to Adriamycin (concentration of drug resulting in 37% cell survival, 4.5 fig/m\) than when treated as monolayer cultures (concentra tion of drug resulting in ...

The cytotoxic activity of Adriamycin was examined in the MGH-U1 human bladder carcinoma line, grown as monolayer culture, as spheroids, and as xenografts in immune-deprived mice. The MGH-U1 cells grown as spheroids were much more resistant to Adriamycin (concentration of drug resulting in 37% cell survival, 4.5 micrograms/ml) than when treated as monolayer cultures (concentration of drug result...

Evolution of resonant frequencies and modes as dependent on the aspect ratio is considered in a dielectric high index spheroid. Because rotational symmetry spheroid solutions are separated by azimuthal $m$. By two-parametric variation refractive we achieve exceptional points at which coalesced sector $m=0$.

We study the low-frequency polarization response of a surface-charged oblate spheroidal particle immersed in an electrolyte solution. Because the charged spheroid attracts counterions which form the electric double layer around the particle, using usual boundary conditions at the interface between the particle and electrolyte can be quite complicated and challenging. Hence, we generalize Fixman...

An ongoing challenge in biomedical research is the search for simple, yet robust assays using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel spheroid assay, wherein spheroids, formed by magnetic 3D bioprinting, contract immediately as cells rearrange and compact the spheroid in relation to viability and cytoskeletal organization. Thus, spheroid size ca...

Models of our galaxy based on dynamical observations predict a spheroid component much heavier than accounted for by direct measurements of star counts and high velocity stars. If, as first suggested by Caldwell and Ostriker, this discrepancy is due to a large population of faint low-mass stars or dark objects in the spheroid, the spheroid could be responsible for microlensing events for source...

A technique has been developed which takes advantage of the spherical symmetry of EMT6/Ro multicellular tumor sphe roids to isolate subpopulations of cells originating from various locations in the spheroid structure. The method involves gently exposing spheroids to a dilute trypsin solution at 18 to 20°in specially designed dishes on a rotary shaker. Under these conditions, cells are released...

Background: Several cell lines when cultured under proper condition can form three dimensional structures called multicellular tumor spheroids. Tumor spheroids are valuable in vitro models for studying physical and biological behavior of real tumors. A number of previous studies using a variety of techniques have shown no relationship between radiosensitivity and DNA strand breaks in monolayer ...

In this paper, we present the results of solution of three-dimensional electromagnetic scattering problems by impedance bodies of revolution, using the Pattern Equations Method (PEM). The good convergence this results is shown on the example of a prolate spheroid and a cylinder with spherical rounding. Key-Words: Scattering pattern, scatterer, impedance, prolate spheroid, cylinder

We show that the observed scatter in the relations between the mass of supermassive black holes (SMBHs), Mbh, and the velocity dispersion σsph or mass Msph of their host spheroid, place interesting constraints on the process that regulates SMBH growth in galaxies. When combined with the observed properties of early-type SDSS galaxies, the observed intrinsic scatters imply that SMBH growth is re...