the most frequent adverse effects of indomethacin like other nsaids are gastro–intestinal and central nervous system disturbances. extended release or enteric release formulations minimize these symptoms. the objective of this study was to develop an extended release pellet formulation of indomethacin by the centrifugation (rotary fluid bed granulation) or powder layering method. layered, nonpa...

this study was conducted to evaluate the effects of feeding mash versus pellet with different thermal process on blood metabolites, carcass characteristics and broiler performance. 192 (one-day) cobb broiler chicks were used in a completely randomized design with 4 experimental groups (diets) and 4 replicates of ten chicks each (totally 16 pens). the experimental treatment groups consisted of m...

In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system .It has good advantage over the conventional dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage f...

Biotechnology revolution had led the overcoming of different types of therapeutic protein because of their chemical structure can perform specific reactions in the body, increasing efficacy and decreasing side effects. Numerous efforts were made to optimize the physicochemical properties of the proteins used for therapeutic and studied different methods for an effective administration of the pr...

The production of the pellets in the pharmaceutical industry generally involves multi-step processing; 1 mixing, 2 wet granulation 3 spheronization 4 drying. Tangential spray rotogranulation is now being considered as an alternative since it combines number of steps into one processing unit thus reduces processing time. This work aimed to development and doe analysis of GPCG125 and optimization...