The central nervous system (CNS) encompasses the brain and spinal cord is considered processing center most vital part of human body. barriers are crucial interfaces between CNS periphery. Among all these biological barriers, blood-brain barrier (BBB) strongly impede hurdle for drug transport to brain. It a semi-permeable diffusion against noxious chemicals harmful substances present in blood s...

spinal muscular atrophies (smas) represent a rare group of inherited disorders that cause progressive degeneration of the anterior horn cells of the spinal cord. the exact cause of the degeneration is unknown. loss of these cells results in a progressive lower motor neuron disease that has no sensory involvement and that is manifested as hypotonia, weakness, and progressive paralysis. kugelberg...

Background & Importance: Spinal deformity is one of the most common disorders among the vertebral diseases that results from unnatural curvatures of spine, such as scoliosis and kyphosis. Spinal fusion surgery is used most commonly to treat certain types of spinal deformity. Herein, we reported the efficacy of posterior spinal fusion accompanied by instrumentation in patients with the...

STUDY DESIGN Retrospective patient data collection and investigator survey. PURPOSE To investigate patterns of opioid treatment for pain caused by spinal disorders in Korea. OVERVIEW OF LITERATURE Opioid analgesic prescription and adequacy of consumption measures in Korea have markedly increased in the past decade, suggesting changing patterns in pain management practice; however, there is ...

© 2015 The Author(s). Published by Taylor & Francis on behalf of the Nordic Orthopedic Federation. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/3.0) DOI 10.3109/17453674.2015.1072431 In this issue of Acta Orthopaedica 2 articles (Clement et al. 2015, van Hooff et al. 2015) repres...

Intramedullary schwannomas are a rare form of spinal tumors. Here, we present case 61-year-old woman who was admitted to our hospital with complaints weakness in both lower extremities, numbness, urinary and defecation disorders, radiculating back pain. Physical examination revealed sensory motoric deficits the as well autonomical dysfunctions. Radiological imaging mass at level thoracic segmen...

In this chapter we will review a variety of neurological disorders that result from abnormalities of bones, ligaments, and other mesenchymal tissue that compress the nervous system. Most of these conditions are degenerative in nature, although some represent developmental disorders. The spinal cord and occasionally nerve roots are the nervous tissues most commonly compressed. One condition, dis...

treatment recommendations can be offered. Some spinal neurologic diseases, such as many of the spinal degenerative disorders, either are not treatable or have no globally accepted treatment. For those diseases with established treatments, general treatments include either non-surgical (medical) or surgical treatments. Rehabiliation, physical therapy, and pain management are also important aspec...

Introduction: Tuberculosis is still commonly found in many developing countries. Spinal tuberculosis can cause vertebral deformity and neurological disorders. It was discovered thousands years ago its management aimed to eradicate infection maintain the integrity of vertebrae. Previously, spinal TB using drugs external stabilization. Surgical techniques were developed afterwards clean infected ...

The article focuses on the evaluation of special therapy with neural mobilization aimed at observation effect a subjective parameter - pain patients who have been diagnosed lumbar nerve entrapment syndrome. Neurodynamic disruption is an inseparable part clinical manifestation connected pathological processes and changes in strain periradicular perineural area manifested symptomatology roots. Fo...