Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether this model is responsive to selective serotonin reuptake inhibitors remains unspe...

STUDY DESIGN Retrospective cohort study. OBJECTIVE To investigate the relationship between radiological signs of Scheuermann disease (SD) and low back pain (LBP) in a local population using lumbar magnetic resonance (MR) images. SUMMARY OF BACKGROUND DATA SD is a spinal disorder, and both its classic and atypical (lumbar) forms are associated with LBP. However, radiological signs of SD are ...

It has long been hypothesized that morphological and numerical alterations in dendritic spines underlie long-term structural encoding of experiences. Here we investigate the efficacy of aversive experience in the form of acute immobilization stress (AIS) and chronic immobilization stress (CIS) in modulating spine density in the basolateral amygdala (BLA) of male rats. We find that CIS elicits a...

BACKGROUND Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), signaling represent potential therapeutic targets for major depressive disorder. The purpose of this study is to examine whether TrkB ligands show antidepressant effects in an inflammation-induced model of depression. METHODS In this study, we examined the effects of TrkB agonist 7,8-dih...

Experience-driven circuit changes underlie learning and memory. Monocular deprivation (MD) engages synaptic mechanisms of ocular dominance (OD) plasticity and generates robust increases in dendritic spine density on L5 pyramidal neurons. Here we show that the paired immunoglobulin-like receptor B (PirB) negatively regulates spine density, as well as the threshold for adult OD plasticity. In Pir...

background & importance: cavernous angiomas are typically superficial lesionscreated by anomalous vessels and found in the skin or mucosa, but intradural locations are rare especially in the spine. we report a case of the spinal intradural cavernous angiomas of the lumbar spine. case presentation: a 53-year-old man presented with a 6-month history of low back pain and bilateral radicular pain. ...

Layer 1 of the cortex contains populations of neurochemically distinct neurons and afferent fibers which markedly affect neural activity in the apical dendritic tufts of pyramidal cells. Understanding the causal mechanisms requires knowledge of the cellular architecture and synaptic organization of layer 1. This study has identified eight morphological classes of calretinin immunopositive (CRet...

The cover image is based on the Original Article Muscleblind-Like 2 knockout shifts adducin 1 isoform expression and alters dendritic spine dynamics of cortical neurons during brain development by Chia-Wei Huang et al., https://doi.org/10.1111/nan.12890.

background & importance: hydatid disease of the spine is rare but constitutes approximately 50% of bone involvement cases in human hydatidosis. it is a severe condition associated with a high rate of morbidity, disability and mortality. case presentation: in the present paper, we report an intriguing case of cervical spinal hydatid disease mimicking traumatic burst fracture. conclusion: a high ...