O NE OF the primary nlanifestations of tile clinical entity tropical sprue is a severe megaloblastic anemia. Although detailed descriptive information is available on tile blood and bone marrow morphology of this anenlia, its pathogenesis remains obscure.4’ The purpose of this report is to describe the quantitative aspects of red! cell production and dlestruction in this anemia. Our observation...

A case is described of adult coeliac disease with subepithelial collagen in a jejunal biopsy ('collagenous sprue') which responded well to treatment with prednisolone in addition to a gluten-free diet. The indications for corticosteroid treatment in adult coeliac disease are discussed in the light of the findings. It is suggested that collagenous sprue may represent the most severe form of adul...

Collagenous sprue (CS) is a progressive malabsorptive disorder characterized by collagen deposition beneath the basement membrane of small bowel epithelium in refractory celiac sprue. CS is a pathologically distinct entity from celiac disease, despite a similar clinical presentation. The etiology of CS is unclear, although there are speculations that CS and celiac disease may share similar path...

It has been said repeatedly1' 2'3 but erroneously that Vincent Ketelaer described tropical or non-tropical sprue in his book De Aphthis Nostratibus.4 The error arises because it has not been understood that the Dutch word sprouw, as Ketelaer used it, meant and meant only stomatitis. In particular, as can be seen from Ketelaer's description, it meant mainly thrush, the common monilial infection ...

While investigating the subject of " tropical ansemias with special reference to pernicious anaemia " at the Carmichael Hospital for Tropical Diseases, Calcutta, it has been found that there is a striking resemblance between the blood picture in cases of advanced sprue and the blood picture of Addisonian ansemia. A close and thorough study has been made of 27 cases of sprue from the clinical, l...