background: the aim of this study was to present epidemiological aspects of malignant tumor of head and neck in southeast of iran, with a view toward analyzing the age, gender, site distribution and histological types.  methods: all cases with malignant tumor of the head and neck region from 1999 to 2009 were retrieved from the records of cancer registry center of kerman university of medical s...

introduction: sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far.in the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer.   materials and methods: patients with biopsy-proven squamous cell carcinoma of the larynx were included...

to evaluate the effect of adding neoadjuvant chemotherapy to surgery and radiation therapy for locally advanced resectable oral cavity squamous cell carcinoma, 24 patients with t3 or t4a oral cavity squamous cell carcinoma were randomly assigned to surgery alone or docetaxel, cisplatin, and 5-fu (tpf) induction chemotherapy followed by surgery. all patients were planned to receive chemoradiothe...

background and objective: the frequency and pattern of eye neoplasms differ in various geographic areas. our aim was to determine the distribution of patient age, gender, ocular tumor origin, location and histological type in our region. materials and methods: in this cross-sectional study, all of the 384 eye globe enucleation cases carried out during a 10-year period in farabi medical center i...

introduction: diagnosis, prediction and control of oral lesions is usually done classically based on clinical signs and histopathologic features. due to lack of timely diagnosis in all conventional methods or differential diagnosis, biopsy of patient is needed. therefore, the patient might be irritated. so, an intelligent method for quick and accurate diagnosis would be crucial. intelligent sys...

previous studies on etiology of squamous cell carcinoma (scc) of the tongue have reported results with respect to long term exposure to cigarette smoking and alcohol abuse. the aim of this study was to investigate risk factors for scc of the tongue in a set of patients with minimum exposure to cigarette smoking and alcohol. sixty four cases with diagnosis of oral tongue scc were reviewed in thi...

background: the aberrant expression of dickkopf-1 (dkk1), triose phosphate isomerase (tpi) and fatty acid binding-protein 5 (fabp5) in lung cancer tissues and their presence in secretome of lung cancer cell lines were reported. here, serum levels of these molecules in lung cancer patients were compared to those in a healthy control group. materials and methods: the patients’ group consisted of ...

abstract background: esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. this may be due to increasing rates of barrett’s esophagus, gastroesophageal reflux, smoking and obesity. this study was performed from 1991 to 2005 in order to evaluate variou...

background and aim: squamous cell carcinoma is the eighth common cancer and forms 94% of oral malignancies. nowadays, many molecular and genetic changes have been known to affect tumoral behavior which might be good for drug production and gene therapy. it has been known that mutated p53, overexpression of p63 as an oncogene and hpv infection are correlated with clinicopathological behavior of ...

telomerase activation is one of the main pathways to immortalize cancer cells. in many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural habits...