serotonin (5-ht), a mono-aminergic neurotransmitter is biochemically derived from tryptophan and is mainly found in gastrointestinal tract, platelets and central nervous system of animals. serotonin (5-ht) in coordination with hypothalamus plays an important role in the cns control of appetite, eating behavior, and energy balance and body weight. it has a special role in control of carbohydrate...

INTRODUCTION We describe seven cases of patients with an inability to cry after treatment with selective serotonin re-uptake inhibitor (SSRI) medication, even during sad or distressing situations that would have normally initiated a crying episode, in the light of the role of the serotonergic system in emotional expression. METHOD Case series drawn from patients attended in a secondary care p...

antidepressants and have been used to treat mood disorders, such as depression and anxiety disorder. Selective serotonin reuptake inhibitors such as citalopram selectively block serotonin transporter (5-HTT) activity, inhibit the reuptake of serotonin (5-HT) into the presynaptic cell and lead to increasing extracellular levels of 5HT. Although clinical trials have shown that SSRIs typically hav...

Background Animal studies indicate a potential protective role of antidepressant medication (ADM) in models colitis but the effect their use humans with ulcerative (UC) remains unclear. Objective To study relationship between ADM and corticosteroid dependency UC. Design Using Clinical Practice Research Datalink we identified patients diagnosed UC 2005 2016. We grouped according to serotonin sel...

BACKGROUND Selective serotonin reuptake inhibitors (SSRI) are established first-line pharmacological treatments for obsessive-compulsive disorder (OCD), while antipsychotics are used as an augmentation strategy for SSRI in OCD patients who have either no response or a partial response to SSRI treatment. The goal of the present study was to identify genetic variants and pathways that are associa...

Ten per cent of British males report that they 'sometimes' or 'often' experience premature ejaculation. American researchers ( Pryor et al 2006 ) report on two large double-blind randomised studies assessing the efficacy and safety of dapoxetine, a short-acting, selective serotonin-reuptake inhibitor (SSRI) to be used on-demand for treatment of the condition. Accompanying commentary.

BACKGROUND AND PURPOSE Selective serotonin reuptake inhibitors (SSRI) are widely prescribed. Several reports have observed an increased bleeding risk associated with SSRI use, which is hypothesized to be secondary to their antiplatelet effect. METHODS We tested the hypothesis that SSRIs increase the risk for or potentiate the risk of hemorrhagic stroke associated with antiplatelets and antico...

Childhood social anxiety is associated with significant social and academic impairment. The purpose of this study was to compare and contrast the efficacy of two major treatments for social anxiety disorders in children: cognitive-behavioral therapy and selective serotonin reuptake inhibitor (SSRI) drug treatment. Treatment studies in the literature were evaluated using meta-analytic techniques...