Normal pregnancy is associated with a mild systemic inflammatory response and an immune bias towards type 2 cytokine production, whereas pre-eclampsia is characterized by a more intense inflammatory response, associated with endothelial dysfunction and a type 1 cytokine dominance. Interleukin (IL)-33 is a newly described member of the IL-1 family, which binds its receptor ST2L to induce type 2 ...

BACKGROUND Hantaan virus (HTNV) causes a severe lethal haemorrhagic fever with renal syndrome (HFRS) in humans. Despite a limited understanding of the pathogenesis of HFRS, the importance of the abundant production of pro-inflammatory cytokines has been widely recognized. Interleukin 33 (IL-33) has been demonstrated to play an important role in physiological and pathological immune responses. A...

Abstract Background IL-33/ST2 axis and gut microbiota are important factors in the pathogenesis of IBD with a potential reciprocal influence. controls mucosal healing process during intestinal inflammation. Pouchitis, after restorative proctocolectomy ileal pouch-anal anastomosis, is most common complication. We aimed to explore correlation between cytokines inflammatory pouchitis. Methods 23 p...

The c-Jun N-terminal kinases (JNKs) are encoded by three genes that yield 10 isoforms through alternative mRNA splicing. The roles of each JNK isoform in the many putative biological responses where the JNK pathway is activated are still unclear. To examine the cellular responses mediated by different JNK isoforms, gain-of-function JNK1 polypeptides were generated by fusing the upstream mitogen...

Abstract Background Colorectal cancer associated to chronic colitis (CAC) has a different pathogenesis compared sporadic or familial colorectal and represents the major complication of IBD. IL-33 its receptor, ST2, are important factors in Emerging evidence suggests potential contribution inflammation-driven tumorigenesis that can lead CAC. The aim our study was characterize precise IL-33/ST2 a...

IL-33 is constitutively expressed in the skin. Psoriasis a common skin inflammatory disease. The roles of psoriasis have not been well-elucidated. We identified that keratinocytes (KCs) are predominant cells expressing and its receptor, suppression tumorigenicity 2, KCs actively released on stimuli induced psoriasis-related cytokine, chemokine, molecules genes transcription an autocrine manner....