Stachybotrys chartarum is a toxigenic fungus that has been associated with human health concerns such as nasal bleeding in adults and pulmonary hemosiderosis (PH) in infants. Seven of eight strains of S. chartarum isolated from homes of infants with PH in Cleveland, Ohio, and the strain from the lung of an infant with PH in Texas produced stachylysin in tryptic soy broth (TSB), whereas only one...

Stachybotrys chartarum is a greenish-black mold in the fungal division Deuteromycota, a catch-all group for fungi for which a sexually reproducing stage is unknown. It produces asexual spores (conidia). The morphology and color of conidia and other structures examined microscopically help distinguish the species from other molds found in indoor air that may contaminate materials in buildings th...

A novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitor, designated epi-cochlioquinone A has been isolated from the fermentation broth of Stachybotrys bisbyi SANK 17777. The molecular formula, physicochemical properties, NMR spectroscopic analysis and X-ray crystallographic analysis revealed that this compound was a stereoisomer of cochlioquinone A, which has been previously reported as...

This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, m...

Plasminogen is a circulating zymogen of plasmin, a primary fibrinolytic enzyme1}.Plasminogen binding to fibrin and vascular and blood cells increases the local concentration of the zymogenand accelerates the activation of plasminogen by plasminogen activators2). We have previously isolated a novel fungal triprenyl phenol, designed staplabin, which enhances plasminogen binding to fibrin and cult...

Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold...

Bioaerosol containing fungal spores became public health hazards. The aerosols contain the of different species Aspergillus, Cladosporium, Chaetomium, Penicillium, Wallemia, Stachybotrys etc. and caused various life-threatening respiratory diseases such as hypersensitivity, pneumonia, Aspergillosis, Candidiasis, Mucormycosis, Cancer, They are easily transmitted from one individual to another. a...