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Objectives. This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage. Methods. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoc...
Due to its ability to capture nonlinear dependencies between random variables, mutual information as an information theoretic measure of correlation is particularly suitable and well-established for the registration of images across different image modalities [4]. Several variants of mutual information measures have been proposed in the context of image registration, most notably Viola-Wells mu...
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