lent, considered by many to be one of the best sailing areas in the country, provided an opportunity not to be missed. Although my initial trip out was in a yacht, most of my early experience was in dinghies less expensive to buy and to repair if damaged. The first dinghy I shared was with three other equally inexperienced friends. We bought a 14 foot fibre glass family dinghy through Exchange ...

When it is not actively transporting cargo, conventional Kinesin-1 is present in the cytoplasm in a folded conformation that cannot interact effectively with microtubules (MTs). Two important and largely unexplored aspects of kinesin regulation are how it is converted to an active species when bound to cargo and the related issue of how kinesin discriminates among its many potential cargo molec...

The paper describes a monitoring system specially designed for cloud infrastructures. We identify the features that are relevant for the task: scalability, that allows utilization in systems of thousands of nodes, flexibility, to be customized for a large number of applications, openness, to allow the coexistence of user and administration monitoring. We take as a starting point the Nagios moni...

DOI: 10.1002/advs.201700872 Who would have believed it? When we launched Advanced Science in December 2014, everyone in the editorial team agreed that it was a fantastic idea to create a forum for top science, open to read, download, and share with everyone, but the development that this young journal has undergone during the last three years has stunned even the most optimistic among us. Figur...

Objective To examine the cost and cost effectiveness of quarterly CD4 cell count and viral load monitoring among patients taking antiretroviral therapy (ART). Design Cost effectiveness study. Setting A randomised trial in a home based ART programme in Tororo, Uganda. Participants People with HIV who were members of the AIDS Support Organisation and had CD4 cell counts <250 ×10 cells/L or World ...

OBJECTIVE To examine the cost and cost effectiveness of quarterly CD4 cell count and viral load monitoring among patients taking antiretroviral therapy (ART). DESIGN Cost effectiveness study. SETTING A randomised trial in a home based ART programme in Tororo, Uganda. PARTICIPANTS People with HIV who were members of the AIDS Support Organisation and had CD4 cell counts <250 × 10(6) cells/L...

The kinetics; evolution of molar mass; solution conductivity, sigma; intrinsic viscosity; and average composition drift; and distribution were determined by monitoring the synthesis of copolymeric polycations of acrylamide (Am) and [2-(acryloyloxy)ethyl]-trimethylammonium chloride (Q9). The quantitative relationship between diminishing sigma and charged co-monomers incorporation was monitored f...

The membership committee of the American Academy of Pedodontics is endeavoring to provide information to new pedodontists about starting a practice. This article in,dudes several factors to consider in preparing a practice. They are: 1. Choosing a dental practice arrangement 2. Selecting and planning a solo practice 3. Choosing an area 4. Choosing a practice facility 5. Finding support services...

The paper analyses the challenges involved in constructing a dynamic monitoring framework compliant with the requirements of SOA application monitoring. The specification of these requirements provides a starting point for our multilayer framework architecture. We describe its Monitoring Scenario and Instrumentation layers in detail. The approach aims at runtime monitoring of container-based SO...