Introduction: DCE MRI has been proposed to assess human acute ischemic stroke (AIS) patients, by evaluating leakage of contrast across the compromised blood brain barrier (BBB), and correlating these findings to clinical outcomes including hemorrhagic transformation (HT). Previous work has shown a correlation between the quantitative permeability measure, KPS, and HT [1]. However, successful es...

Hashimoto's thyroiditis (HT) has been characterized for many years as a well-defined clinicopathologic entity, but is now considered a heterogeneous disease. IgG4-related HT is a new subtype characterized by thyroid inflammation rich in IgG4-positive plasma cells and marked fibrosis. It may be part of the systemic IgG4-related disease. We report a case of a 56-year-old Portuguese man who presen...

INTRODUCTION Some providers report concern for the safety of transgender hormone therapy (HT). METHODS This is a systematic literature review of HT safety for transgender adults. RESULTS Current literature suggests HT is safe when followed carefully for certain risks. The greatest health concern for HT in transgender women is venous thromboembolism. HT among transgender men appears to cause...

Autoimmune thyroid disease (AITD) shows the highest incidence among organ-specific autoimmune diseases and is the most common thyroid disease in humans, including Graves' disease (GD) and Hashimoto's thyroiditis (HT). The susceptibility to autoimmune diseases is affected by increased autoantibody levels, susceptibility gene polymorphisms, environmental factors, and psychological factors, but th...

the renin-angiotensin-aldosterone system (raas) plays pivotal roles in the pathogenesis of chronic kidney disease (ckd) progression and its increased complications such as hypertension (ht) and cardiovascular diseases (cvd). previous studies suggested that aliskiren a direct renin inhibitor, blocks raas and may be effective for the management of ckd and its complications. this review focuses on...

PURPOSE Hereditary thrombophilia (HT) is a major risk factor for idiopathic pulmonary embolism (iPE) and shows different prevalence among ethnic groups. The prevalence and clinical characteristics of HT in Korean patients with iPE were investigated. MATERIALS AND METHODS Patients with PE on computed tomography (CT) scan were recruited, and those with malignancy were excluded. Patients were di...

PurposeCardiac re-transplantation (reTX) in pediatrics remains a rare occurrence, representing only 2% of all pediatric heart transplants (HT). The purpose this study was to describe the pre-transplant characteristics, waitlist outcomes and post-HT for reTX at our center.MethodsRetrospective review patients listed transplantation (HT) from 1/1/2014-10/18/2021. Pre-transplant characteristics pos...

The presynaptic serotonin (5-HT) transporter (SERT) is a key regulator of 5-HT signaling and is a major target for antidepressant medications and psychostimulants. In recent years, studies of natural and engineered genetic variation in SERT have provided new opportunities to understand structural dimensions of drug interactions and regulation of the transporter, to explore 5-HT contributions to...

5-Hydroxytryptamine(2A) (serotonin(2A), 5-HT(2A)) receptors are important for many physiologic processes including platelet aggregation, smooth muscle contraction, and the modulation of mood and perception. A large number of pharmaceutical agents mediate their actions, at least in part, by modulating the number and/or activity of 5-HT(2A) receptors. Drugs with action at 5-HT(2A) receptors are u...

Serotonin (5-HT)3 receptors are the only ligand-gated ion channel of the 5-HT receptors family. They are present both in the peripheral and central nervous system and are localized in several areas involved in mood regulation (e.g., hippocampus or prefrontal cortex). Moreover, they are involved in regulation of neurotransmitter systems implicated in the pathophysiology of major depression (e.g....