introduction: the traditional goal of the treatment of acute myelogenous leukemia is to produce and maintain a complete remission (cr).the difference in survival time was entirely attributable to the duration of time spent in cr .in this study, the outcome of aml patients with allogeneic hsct in cr1 versus other than cr1 was compared. patients and methods: since march 1991 until november 2008, ...

hematology- oncology and stem cell transplantation research center related to tehran university of medical sciences located in shariati hospital. these center activities have started in 1991 in order to help needful patients and augment new data to reach new aspects of therapeutic trials. also it is one of the greatest stem cell transplantation centers in world and is the second center in the w...

objective: to evaluate the potential advantages of imipenem/cilastatin in control of fever in neutro-penic hsct recipients.patients and method: in this single-center study, 111 consecutive febrile episodes in 104 neutropenic hsct recipients with a mean age of 26 years were randomized to treatment either with imipenem/cilastatin 1 g, iv, q8h or cefepime (our standard regimen) 2 g, iv, q8h. if fe...

linezolid (lzd), severed as the first oxazolidinone antibiotic, was active against multidrug-resistant gram-positive strains. lzd can induce thrombocytopenia, anemia and leukocytopenia. currently, reports on pure red cell aplasia (prca) cases induced by lzd are relatively rare [4-7]. in this paper, we reported a patient with prca twice induced by lzd. a 37-year-old man was diagnosed with myelody...

stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. however, long-term efficacy and safety of these novel modalities still remain a serious question. hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. fift...

introduction: acute promyelocytic leukemia treatment revolutionized by new tretamnets. currently number of patinets who undergoe hematopoietic stem cell transplantation decrased so experience with this modality is limited. here we report our experience with stem cell transplantation in acute promyelocytic leukemia patients. design and setting: retrospective, single center methods: between year ...

Background: This article reviews experimental and clinical studies in which neural injuries repaired with bone marrow stromal cells. History: Bone marrow contains two kinds of stem cells: hematopoietic and nonhematopoietic (stromal) stem cell. In vitro studies indicate that bone marrow stromal cells have the capacity of differentiation into other cells (such as neural cell) under treatment wit...

Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Human neural stem cells cultured in self-assembling peptide scaffolds have been proposed as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/...