Background Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six 18F-labeled radiopharmaceuticals produced on a routine basis at the University of Pennsylvani...

1. Hematogenous E. coli pyelonephritis was produced in rats. The localization of the organisms and the persistence of bacterial antigens was followed by fluorescent antibody techniques as well as by standard histological and bacteriological methods. 2. Salient sequential features were as follows: Single organisms passed through vessel walls into the renal interstitium and began multiplication a...

The low-molecular-weight, heat-stable type of Escherichia coli enterotoxin (ST) was obtained from sterile syncase broth filtrates of human and animal enteropathogenic E. coli strains. ST was assayed in infant mice, and it was found that this assay was specific for ST in that the high-molecular-weight, heat-labile type of E. coli exterotoxin would not cause fluid accumulation in these animals. S...

The current article is a review of the public health risks attributable to waterborne pathogens in health care. The consequences of health care-associated infections (HAIs) are discussed. Not only are Legionella spp involved in HAIs, but also Pseudomonas aeruginosa, other gram-negative microorganisms, fungi, and amoeba-associated bacteria. This is particularly noteworthy among immunocompromised...

Ionogel fiber mats were made by electrospinning poly(methylmethacrylate) (PMMA) and the ionic liquid (IL) bis(1-butyl-3-methyl-imidazolium) tetrachloridocuprate(II), [Bmim]2[CuCl4], from acetone. The morphology of the electrospun ionogels strongly depends on the spinning parameters. Dense and uniform fiber mats were only obtained at concentrations of 60 to 70 g L−1 of polymer and IL mass combin...

economical way of producing an on-line pharmaceutUltrafiltration (UF ) is a membrane filtration process ical grade solution (sterile and non-pyrogenic) used based on a molecular sieving exclusion [1]. The use of for substitution fluid. In this case, UF acts as a ‘cold UF in renal replacement therapy (RRT) has been sterilizing’ process. (ii) The enhanced blood purificareported in various fields ...

Experimental enterocolitis was induced in guinea pigs by intraperitoneal injection of clindamycin. Specimens of feces were collected daily in phosphate-buffered saline (pH 7.0) and pooled every second day. The pooled samples were centrifuged to remove solids, and the supernatant was sterilized by membrane filtration. The sterile fecal supernatants were then dialyzed for 48 h against two 15-lite...

Balloting on a new test method for use in the ranking of porous packaging materials used in sterile packaging applications by their ability to provide bacterial holdout was completed in July 2007 by ASTM International Committee F02 Flexible Barrier Packaging. As a result of this balloting, there is a new test method available for evaluating the barrier capabilities of porous materials intended ...