the newborn who is born before terms is a candidate for the development of idiopathic respiratory distress syndrome. the intense hypoxia and acidosis that ensue as the consequence of inadequate alveolar-capillary exchange of oxygen and carbon dioxid may prove fatal antenatal steroid therapy can affect rds (respiratory distress syndrom) and its complications. the newborn before 34 weeks have a s...

     1,3-dialkyl 3-phenylpyrrolidine-2, 5-diones were modified to produce potential steroid sulphatase inhibitors. These modifications were aimed at producing compounds, which could be expected to bind reasonably well to the active site of the steroid sulphatase enzyme but could not be hydrolyzed readily by the enzyme due to the covalent S-C bond present. In this regard the sulphinic acid deriv...

background: molecular biomarkers are valuable in evaluation the course of malignancies. in this study, the relationship be­tween her2/neu, p53, steroid receptors and clinicopathological features of patients with breast cancer has been assessed. methods : three hundred thirty nine women with a primary diagnosis of breast cancer from 2001 to 2006 were included. they were evaluated for tumor featu...

introduction: the aim of the present study was to investigate the effectiveness of high-fiber diet on sexual hormones in obese and overweight female adolescents. methods: this randomized crossover clinical trial was conducted among 56 obese or overweight girls in shiraz, iran. all subjects were randomly divided into two groups. a list containing high (25 g/day green leafy vegetables or fresh fr...

objective: rna interference (rnai) is the most potent technique for gene silencing in eukaryotic cellular system at transcriptomic level. genetic disorders and cancers are important targets for therapeutic development of this technique. in order to bypass the temporary dpwnregulation by sirna, a new generation of shrna named shrnamir has developed. silencing construct with structure similar to ...

introduction anabolic-androgenic steroids (aas), a synthetic derivate of testosterone, have become a popular drug among athletes and bodybuilders to enhance muscle mass and improve the athletic performance. many pathological effects such as hepatic and endocrine dysfunction, behavioural changes and cardiovascular complications have been reported. case report within these ast ones, we find an in...