I read with interest the case report by Tuggey and Hosker where Churg-Strauss syndrome was associated with the use of montelukast in an asthmatic patient in whom there was no recent exposure to oral corticosteroid. However, it is worth noting that the patient was using a high dose of inhaled fluticasone propionate (1.5 mg/day) via a large volume spacer prior to the introduction of montelukast. ...

Shanghai, China, postulated that MVP may have been the result of structural damage and functional derangement caused by the underlying vasculitis of BD. Whereas the association of MVP and BD may be either causally related or coincidental, it is important to keep in mind that, although BD is relatively rare in the United States, MVP is very common. BD occurs most frequently in Japan and in the M...

Eosinophilic granulomatosis with polyangiitis formerly named “Churg-Strauss syndrome (CSS)” is a systemic disease with bronchial asthma, hypereosinophilia, and systemic vasculitis. We report a case of CSS with cholecystitis and mononeuritis multiplex. A 50-year-old woman with a history of sinusitis and bronchial asthma of 8 years’ duration was referred with a complaint of left-hand deformity an...

A 57-year-old man with a history of more than 10 years of bronchial asthma and chronic sinusitis complained of double vision which developed 18 days after cardiac tamponade with eosinophil-rich fluid (eosinophils 30%). He had oculomotor nerve palsy, and a blood test revealed eosinophilia (12,700/mm(3)) and elevation of both C-reactive protein and rheumatoid factor. He was diagnosed as having Ch...

Several cases of eosinophilic conditions including Churg-Strauss syndrome (CSS) have recently been reported in asthmatic patients being treated with antileukotriene receptor antagonists. One patient with CSS who experienced a clinical relapse after treatment with montelukast and two asthmatic patients who developed CSS while receiving montelukast treatment are described. In one case reduction i...

Several cases of eosinophilic conditions including ChurgStrauss syndrome (CSS) have recently been reported in asthmatic patients being treated with antileukotriene receptor antagonists. One patient with CSS who experienced a clinical relapse after treatment with montelukast and two asthmatic patients who developed CSS while receiving montelukast treatment are described. In one case reduction in...

CHURG-STRAUSS SYNDROME Churg-Strauss syndrome is a rare small vessel vasculitis manifested by fever, asthma, and hypereosinophilia. This disease is also referred to as allergic angiitis and granulomatosis, • A patient’s combined genetic predisposition and regulatory mechanisms control expression of the immune response to antigens. • Negative test results for antineutrophil cytoplasmic antibodie...

A 28-year-old woman with a history of asthma and recent deep venous thrombosis presented with fever, chest pain, and peripheral eosinophilia. The patient was subsequently diagnosed with Churg-Strauss syndrome and HIV infection, representing to our knowledge only the second case of this association. Rheumatologic manifestations of HIV may precede clinical signs of infection. This is significant ...

Adjuvant medical treatment steroid therapy of polyarteritis nodosa. Specific treatments are sometimes required. 55: 146–155 renal vasculitis. Angiotensin converting enzyme inhib-10. Guillevin L, Jarrousse B, Lok C et al. Long-term followup after itors or angiotensin II-receptor blockers are effective treatment of polyarteritis nodosa and Churg–Strauss angiitis and able to control severe or mali...

This paper records a patient of Osler's, who showed many features compatible with the Churg-Strauss syndrome of allergic granulomatous angiitis to be described 50 years later.