OBJECTIVES To investigate the effect of triclosan exposure on the antimicrobial susceptibilities of numerically important dental bacteria. METHODS A gradient plate technique was used to expose Fusobacterium nucleatum, Lactobacillus rhamnosus, Neisseria subflava, Porphyromonas gingivalis, Actinomyces naeslundii, Prevotella nigrescens, Streptococcus oralis, Streptococcus sanguis, Streptococcus ...

emierre’s syndrome consists of a pharyngeal infection assoiated with septicemia and internal jugular thrombosis with eptic emboli. This condition was described in 1936 by ndre Lemierre.1,2 It was initially named as post-anginal epticemia, and then, ‘‘forgotten disease’’, by becoming rare condition after the advent of antibiotics, with fewer han 100 cases reported since 1974.2 Lamierre’s syndrom...

OBJECTIVES Ciprofloxacin is the most frequently used member of the fluoroquinolones during initial eradication therapy of Pseudomonas aeruginosa, as well as during acute pulmonary exacerbations. However, its long-term effect on the susceptibility of the commensal flora within the cystic fibrosis (CF) airways has not yet been examined. The aim of this study was therefore to examine the consequen...

Hydrogen peroxide (H2O2) produced by members of the mitis group of oral streptococci plays important roles in microbial communities such as oral biofilms. Although the cytotoxicity of H2O2 has been widely recognized, the effects of H2O2 produced by oral streptococci on host defense systems remain unknown. In the present study, we investigated the effect of H2O2 produced by Streptococcus oralis ...

The effects of sealing infected carious dentine below dental restorations on the phenotypic and genotypic diversity of the surviving microbiota was investigated. It was hypothesized that the microbiota would be subject to nutrient limitation or nutrient simplification, as it would no longer have access to dietary components or salivary secretion for growth. The available nutrients would be limi...

Mitis-group streptococci are ubiquitous oral commensals that can promote polybacterial biofilm virulence. Using a novel murine oral mucosal co-infection model we sought to determine for the first time whether these organisms promote the virulence of C. albicans mucosal biofilms in oropharyngeal infection and explored mechanisms of pathogenic synergy. We found that Streptococcus oralis colonizat...

BACKGROUND AND OBJECTIVES Streptococcus pneumoniae, a major human pathogen, is closely related to the commensal species S. mitis and S. oralis. S. pneumoniae surface proteins are implicated in virulence and host interaction of this species, but many of them have recently been detected in S. mitis B6 in silico. We tested for the presence of such genes usinga set of eight S. mitis and eleven S. o...

Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to platelet activation. We demonstrate a critical role for the immune receptor FcγRIIA, αIIbβ3, and Src and Syk tyrosine kinases in platelet activation by Staphylococcus aureus, Streptococcus sanguinis, Stre...

We investigated the initial adhesion in vitro of oral streptococci to porcelain inlays. Four strains of streptococci, Streptococcus mitis NCTC12261, Streptococcus oralis ATCC9811, Streptococcus sanguis ATCC10556 and Streptococcus sobrinus OMZ176, were used in this study. The disc specimens were made of porcelain, composite resin cement and human enamel. These specimens, with or without a saliva...