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Current understanding of the effects of damage on neural networks is rudimentary, even though such understanding could lead to important insights concerning neurological and psychiatric disorders. Motivated by this consideration, we present a simple analytical framework for estimating the functional damage resulting from focal structural lesions to a neural network model. The effects of focal l...

OBJECTIVES Radiological cervical spine involvement in JIA has already been assessed with a large range of prevalence (5-80%), but most studies were performed a long time ago, in symptomatic JIA and without differentiating subsets of JIA. We set out to describe structural cervical spine involvement in young adults with polyarticular JIA (pJIA) regardless of the cervical symptoms and to compare l...

Intracranical structural lesions (ISL), lesions associated with morphological changes in the brain or the cranial cavity, are important cause of symptomatic epilepsy. Knowledge of such ISLs in the past were based on selective neuroradiologic investigations, observarions at surgery, pathological examination of surgically resected specimens and autopsy findings. Modern neuroimaging techniques lik...

This thesis investigated structure versus function in the central auditory nervous system (CANS) by using the lesion study approach and by utilising a validated clinical test battery for the assessment of auditory processing as well as selfor parent report measures. The central auditory test results were correlated with the macroscopical appearance o f the CANS on brain MRJ and with patient rep...

A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neurons accompanies functional changes is less clear. Here, we use two-photon ima...

The clinical manifestations of diabetic nephropathy, proteinuria, increased blood pressure, and decreased glomerular filtration rate, are similar in type 1 and type 2 diabetes; however, the renal lesions underlying renal dysfunction in the 2 conditions may differ. Indeed, although tubular, interstitial, and arteriolar lesions are ultimately present in type 1 diabetes, as the disease progresses,...

The renal lesions underlying renal dysfunction are different in type 2 and type 1 diabetes. Renal structure is heterogeneous in type 2 diabetic patients, with only a subset presenting typical diabetic glomerulopathy, as in type 1 diabetes. The remaining patient have more advanced tubulo-interstitial and vascular than glomerular lesions, or normal/near normal renal structure. The clinical manife...

The surgical treatment of pharmacoresistant temporal lobe epilepsy is increasing rapidly. The correlation of preoperative MRI, histopathological findings, and postoperative seizure control is reported for 178 patients with chronic medically intractable temporal lobe epilepsy who were operated on between November 1987 and January 1993. Histopathologically there were distinct structural abnormali...

background: transvaginal ultrasound is one of the most common means to examine endometrial cavity lesions although its negative results are more valuable. saline sonohysterography can reduce the number of false negative rates of endometrial lesions diagnoses in tamoxifen consumers. the objective of this study was to determine the diagnostic values of saline infusion sonohysterography (sis) and ...