More than a decade has passed since adult neurogenesis in the murine telencephalon was described and accepted widely. The adult neurogenesis has been attributed to the progenitors in the subgranular layer in the dentate gyrus and the subependymal layer of the telencephalon. However, the developmental origin of the progenitors in the dentate gyrus and the subependymal layer is poorly understood....

Microglia isolated from the neurogenic subependymal zone (SEZ) and hippocampus (HC) are capable of massive in vitro population expansion that is not possible with microglia isolated from non-neurogenic regions. We asked if this regional heterogeneity in microglial proliferative capacity is cell intrinsic, or is conferred by interaction with respective neurogenic or non-neurogenic niches. By com...

intraosseous ganglia can affect the carpal bones of the hand and must be considered in the differential diagnosis of wrist pain. a 38-year-old female presented with a 14-month history of left wrist pain and a radiolucent cystic lesion was seen computed tomography (ct) scanning. characteristic radiographic findings of a cyst in association with a fine sclerotic rim was apparent. we report an unu...

p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions. Many GCs exhibited HuD and NeuN immunolabeling suggesting a differentiated neural ...

Subependymal nodules (SENs) and subependymal giant cell astrocytomas (SEGAs) are common brain lesions found in patients with tuberous sclerosis complex (TSC). These brain lesions present a mixed glioneuronal phenotype and have been hypothesized to originate from neural stem cells. However, this hypothesis has not been tested empirically. Here, we report that loss of Tsc1 in mouse subventricular...

Subependymal heterotopia (SEH) is a neuronal migration disorder characterized by nodules of gray matter along the lateral ventricular walls and often associated with other brain malformations. We present two cases of SEH associated with ventriculomegaly and cerebellar abnormalities diagnosed by fetal magnetic resonance imaging (MRI) at 20 and 23 weeks' gestation respectively. Fetal MRI findings...

mal cells and a subependymal plate composed of glial cells. Accordingly, these layers give rise to ependymomas, subependymomas, and subependymal giant cell astrocytomas (1). Hemangioblastomas are benign vascular tumors with an uncertain origin. They account for 12% of all intracranial tumors, and are a component of the von Hippel-Lindau syndrome in 30% of cases (2, 3). Hemangioblastomas usually...