BACKGROUND Individuals with substance use disorders (SUDs) are at increased risk for hepatitis C viral infection (HCV), and few studies have explored their treatment responses empirically. The objective of this study was to assess interferon alpha therapy (IFN) completion and response rates among patients with HCV who had a history of comorbid SUDs. More data is needed to inform treatment strat...

BACKGROUND Individuals with Substance Use Disorder (SUD) have lower baseline metabolic activity of the prefrontal cortex (PFC) associated with impairment of cognitive functions in decision-making and inhibitory control. Aerobic exercise has shown to improve PFC function and cognitive performance, however, its effects on SUD individuals remain unclear. PURPOSE To verify the cognitive performan...

Objective. There is a paucity of research on substance use disorders (SUDs) in the elderly psychiatric population. This study examines SUDs in a geriatric psychiatry inpatient service over a 10-year period. Methods. Data from 1788 elderly psychiatric inpatients from a ten-year period was collected. Variables collected included psychiatric diagnoses, SUD, number of psychiatric admissions, and le...

Substance use disorders (SUD) have been associated with dysfunction in reward processing, habit formation, and cognitive-behavioral control. Accordingly, neurocircuitry models of addiction highlight roles for nucleus accumbens, dorsal striatum, and prefrontal/anterior cingulate cortex. However, the precise nature of the disrupted interactions between these brain regions in SUD, and the psycholo...

BACKGROUND Each year, nearly 20 million Americans with alcohol or illicit drug dependence do not receive treatment. The Affordable Care Act and parity laws are expected to result in increased access to treatment through integration of substance use disorder (SUD) services with primary care. However, relatively little research exists on the integration of SUD services into primary care settings....

JEAN REIGNIER, HASSAN SELLAK, RÉMY LEMOINE, ANDRÉ LUBINEAU, GUY MICHEL MAZMANIAN, HÉLÈNE DETRUIT, ALAIN CHAPELIER, PHILIPPE HERVÉ, AND THE PARIS-SUD UNIVERSITY LUNG TRANSPLANTATION GROUP Laboratoire de Chirurgie Expérimentale, Jeune Equipe 324, Centre Chirurgical Marie Lannelongue, Université de Paris Sud, Le Plessis Robinson 92350; and Laboratoire de Chimie Organique et Multifonctionelle, Univ...

la pensée leclézienne du corps obéit au cheminement intellectuel de l’auteur de l’extase matérielle. en héritier de l’existentialisme, le clézio a mis en exergue, bien évidemment tout au début de sa carrière romanesque, la question de l’individu « jeté » dans la société occidentale, pour reprendre une formule de heidegger à propos de l’être jeté dans le temps et dans l’espace. une telle vision ...

OBJECTIVES We sought to assess the incidence and determinants of sudden death (SUD) in mitral regurgitation due to flail leaflet (MR-FL). BACKGROUND Sudden death is a catastrophic complication of MR-FL. Its incidence and predictability are undefined. METHODS The occurrence of SUD was analyzed in 348 patients (age 67 +/- 12 years) with MR-FL diagnosed echocardiographically from 1980 through ...

Findings from neuroscience research hold promise for improved treatments for and prevention of substance use disorders (SUD), but ethical concerns about psychopharmacological research involving SUD may potentially undermine scientific progress. This article reviews the literature pertaining to seven ethical requirements that elucidate a coherent framework for evaluating the ethics of clinical S...

Nearly half of the people suffering from schizophrenia also present with a lifetime history of substance use disorders (SUD), a rate that is much higher than the one seen among unaffected individuals. This phenomenon suggests that the factors influencing SUD risk in schizophrenia may be more numerous and/or complex than those modulating SUD risk in the general population. It is critically impor...